Dr Zhizhong Zhang and colleagues from China conducted a meta-analysis of case-control and cohort studies to analyze this association.
The researchers identified relevant studies by searching PubMed and Embase through 2012.
The research team analyzed 21 articles, which included 580,064 subjects.
The summary odds ratios of gastric cancer for the highest, compared with the lowest, dietary fiber intake was 0.58 with significant heterogeneity among studies.
Stratified analysis for study design, geographic area, source and type of fiber, Lauren’s classification, publication year, sample size, and quality score of study yielded consistent results.
|A 10-g/day increment in fiber intake reduced gastric cancer risk|
Dose-response analysis associated a 10-g/day increment in fiber intake with a significant reduction in gastric cancer risk.
The team found that studies restricted with control for conventional risk factors produced similar results, and omission of any single study had little effect on the combined risk estimate.
The Zhang's commented, "In a meta-analysis, we show that dietary fiber intake is associated inversely with gastric cancer risk; the effect probably is independent of conventional risk factors."
"The direction of the protective association of dietary fiber was consistent among all studies, but the absolute magnitude was less certain because of heterogeneity among the studies."
"Further studies therefore are required to establish this association."