Help
Subscribe


Submit Videos to GastroHep Read For FREE - Our full range of review articles
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Guido Tytgat Profile of Pete Peterson Profile of Peter Cotton Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Rectal NSAIDs are superior to pancreatic duct stents in preventing pancreatitis after ERCP

Rectal nonsteroidal anti-inflammatory drugs are superior to pancreatic duct stents in preventing pancreatitis after endoscopic retrograde cholangiopancreatography, reports the most recent issue of the Clinical Gastroenterology & Hepatology.

News image

Placement of pancreatic duct stents prevents pancreatitis after endoscopic retrograde cholangiopancreatography.

There is evidence that rectal administration of nonsteroidal anti-inflammatory drugs also prevents post-endoscopic retrograde cholangiopancreatography pancreatitis, but the 2 approaches alone have not been compared directly.

Dr Ali Akbar from Minnesota, USA conducted a network meta-analysis to indirectly compare the efficacies of these procedures.

The team searched PubMed and Embase by 2 independent reviewers to identify full-length clinical studies, published in English, investigating use of pancreatic duct stent placement, and rectal nonsteroidal anti-inflammatory drugs to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis.

The team identified 29 studies.

The researchers used network meta-analysis to compare rates of post-endoscopic retrograde cholangiopancreatography pancreatitis among patients who received only rectal nonsteroidal anti-inflammatory drugs, only pancreatic duct stents, or both.

The combination of rectal NSAIDs with rectal stents was not superior to either approach alone
Clinical Gastroenterology and Hepatology

Placement of pancreatic duct stents and rectal administration of nonsteroidal anti-inflammatory drugs were each superior to placebo in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis.

The combination of rectal nonsteroidal anti-inflammatory drugs and stents was not superior to either approach alone.

The doctors assessed that the pooled results showed that rectal nonsteroidal anti-inflammatory drugs alone were superior to pancreatic duct stents alone in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis.

Dr Akbar's team commented, "Based on a network meta-analysis, rectal nonsteroidal anti-inflammatory drugs alone are superior to pancreatic duct stents alone in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis, and should be considered first-line therapy for selected patients."

"However, these findings were limited by the small number of studies assessed, potential publication bias, and the indirect nature of the comparison."

"High-quality, randomized, controlled trials are needed to compare these 2 interventions and confirm these findings."

Clin Gastroenterol and Hepatol 2013: 11(7) :778-783
15 July 2013

Go to top of page Email this page Email this page to a colleague

 01 April 2015

Advanced search
 01 April 2015 
Mortality rates for upper GI bleeds
 01 April 2015 
Analysis of liver fibrosis
 01 April 2015 
Obeticholic acid in primary biliary cirrhosis
 31 March 2015 
Hepatic fat and gallbladder polyps
 31 March 2015 
HCV-HIV co-infection combination therapy
 31 March 2015 
Placement of nasoenteral feeding tubes
 30 March 2015 
Minimally invasive approach in colorectal procedures
 30 March 2015 
Prevalence of IBD in USA residents of Indian ancestry
 30 March 2015 
Treatment of pediatric IBD
 27 March 2015 
Screening for fecal incontinence
 27 March 2015 
Deep remission in Crohn's disease
 27 March 2015 
Sexual functioning in IBD
 26 March 2015 
Survival of untreated hepatocellular carcinoma
 26 March 2015 
Antimicrobial therapy in cirrhosis with spontaneous bacterial peritonitis
 26 March 2015 
Metformin as a chemopreventive agent for Barrett's
 25 March 2015 
Genetics and Crohn's disease
 25 March 2015 
Mortality in Barrett’s–related T1 esophageal adenocarcinoma
 25 March 2015 
Cytomegalovirus and IBD
 24 March 2015 
Prevention of colorectal cancer after screening
 24 March 2015 
Functional GI disorders and body mass index
 24 March 2015 
Quality of life in children with fecal incontinence
 23 March 2015 
Fibrosis in NAFLD vs NASH
 23 March 2015 
The unmasking of Whipple's disease
 23 March 2015 
Predicting the quality of colon cancer care
 20 March 2015 
Screening for Barrett's esophagus
 20 March 2015 
Interventions for eosinophilic esophagitis
 20 March 2015 
Colorectal cancer risk and genetic variants
 19 March 2015 
Dedicated care for diverticular disease
 19 March 2015 
Hypnotherapy for IBS
 19 March 2015 
Poor mental and physical health in HCV
 18 March 2015 
Practice guidelines for colorectal polyps
 18 March 2015 
Out-of-hours endoscopy for upper GI bleeding
 18 March 2015 
H. pylori eradication and lipids
 17 March 2015 
H. pylori test-and-treat program and gastric cancer
 17 March 2015 
Adalimumab in Crohn’s disease
 17 March 2015 

Low-dose PPIs and GI bleeding in patients receiving aspirin

 16 March 2015 
Cholestasis of pregnancy with HCV
 16 March 2015 
Microscopic colitis
 16 March 2015 
Hybrid therapy for H. pylori
 13 March 2015 
Medicare patients and payments to gastroenterologists
 13 March 2015 
Appendectomy in ulcerative colitis
 13 March 2015 

Racial disparities in gluten-sensitive problems

 12 March 2015 
Predicting IBD in IBS patients
 12 March 2015 
Patient knowledge of IBS
 12 March 2015 
Nonceliac gluten sensitivity
 11 March 2015 

Prediction of malignant bile duct obstruction

 11 March 2015 
NAFLD–related hepatocellular carcinoma
 11 March 2015 
Assessment of eosinophilic esophagitis
 10 March 2015 
Risk for gastroesophageal reflux symptoms
 10 March 2015 
Poor disease course in pediatric ulcerative colitis
 10 March 2015 
Outcomes in Crohn's therapy
 09 March 2015 
Fibre usage in ulcerative colitis in remission
 09 March 2015 
Risk of C. difficile upon hospital admission
 09 March 2015 
Gastric Cancer detection during GI endosocopy
 06 March 2015 
Steroid therapy for eosinophilic esophagitis
 06 March 2015 
Second anti-TNF in IBD
 06 March 2015 
Efficacy of Hep E vaccine
 05 March 2015 
EPHXI polymorphism and esophageal cancer risk
 05 March 2015 
Infliximab and immunosuppressant therapy in ulcerative colitis
 05 March 2015 
Neuroendocrine carcinoma of the colon and rectum

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2015 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us