The resistance of Helicobacter pylori to antibiotics is increasing worldwide, lowering its efficacy in current eradication therapies.
Dr Peng Su and colleagues from China evaluated Helicobacter pylori resistance to antibiotics in the southeast coastal region of China.
The team collected 17,731 Helicobacter pylori strains from 8 areas of 2 provinces in coastal southeast China from 2010 to 2012.
The resistance of these strains to 6 antibiotics was tested using the agar dilution method.
The doctors found that the resistance rates to clarithromycin, metronidazole, levofloxacin, amoxicillin, gentamicin and furazolidone were 22%, 95%, 21%, 0.1%, 0.1%, and 0.1%, respectively.
|The percentage of double antibacterial resistant was 26%|
Double, triple and quadruple antibacterial resistant percentages were 26%, 8% and 0.1%, respectively.
The research team found a positive association between the resistance to levofloxacin and to clarithromycin but there was a negative correlation in the resistances to levofloxacin and to metronidazole.
Dr Su's team commented, "The prevalence of Helicobacter pylori resistance to clarithromycin, metronidazole, levofloxacin and multiple antibiotics in coastal southeast China is high."
"Choice of therapy should be individualized based on a susceptibility test in this region of the country."