Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 28 September 2016

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Oral anti-viral agents influence the incidence of hepatocellular carcinoma in Hep B

The latest issue of the Alimentary Pharmacology & Therapeutics investigates the impact of oral anti-viral agents on the incidence of hepatocellular carcinoma in chronic hepatitis B.

News image

There are 5 oral nucleos(t)ide analogues available to treat chronic hepatitis B. 
With the availability of newer agents, their efficacy on incidence of hepatocellular carcinoma is not well described.
 
Dr Singal and colleagues determined the efficacy of oral anti-viral agents in reducing hepatocellular carcinoma risk in relationship with other known factors.
 
Published studies of at least 20 chronic hepatitis B patients treated with an oral anti-viral agent and followed for 2 years were analyzed for incidence of hepatocellular carcinoma per 100 person years follow-up.
The research team noted that pooled homogeneous data from 6 studies showed lamivudine treatment to reduce hepatocellular carcinoma risk by 51% compared with no treatment. 
The hepatocellular carcinoma incidence was 1.3 per 100 person years
Alimentary Pharmacology & Therapeutics

Pooled data from 49 studies of 10,025 treated patients showed a hepatocellular carcinoma incidence of 1.3 per 100 person years, independent of the agent used. 

 
The doctors found that the patient age 50 years and hepatitis B virus-DNA detectability at hepatocellular carcinoma diagnosis increased risk of hepatocellular carcinoma by 2-fold with a 10-fold higher risk among patients with cirrhosis compared with chronic hepatitis. 
 
The team showed patient age, study location and type of study contributed to heterogeneity.
 
Dr Singal's team concluded, "Lamivudine treatment significantly reduces the incidence of hepatocellular carcinoma compared with no treatment." 
 
"However, hepatocellular carcinoma still develops at a rate of 1.3 per 100 patient years in chronic hepatitis B patients receiving an oral anti-viral agent." 
 
"This finding highlights the need for continued hepatocellular carcinoma surveillance, particularly in chronic hepatitis B patients with inadequate viral suppression, older age and cirrhosis."

Aliment Pharmacol & Ther 2013:38(2): 98–106
01 July 2013

Go to top of page Email this page Email this page to a colleague

 28 September 2016 
Global trends in pancreatic cancer mortality
 28 September 2016 
Hep C virus RNA in liver explants
 28 September 2016 
Heterogeneity in endoscopic treatment of Crohn’s
 27 September 2016 
Non-invasive tests of NAFLD
 27 September 2016 
Fecal microbiota transplantation for C.diff in IBD
 27 September 2016 
Fast-track colorectal surgery influences outcomes
 26 September 2016 
Preventing cirrhosis in Hep C with fibrosis
 26 September 2016 
Body image after abdominoperineal excision for rectal cancer
 26 September 2016 
Gastric cancer risk in intestinal metaplasia of the stomach
 23 September 2016 
Sleep quality in nonalcoholic cirrhotic patients
 23 September 2016 
Exercise for NAFLD
 23 September 2016 
BMI history and fatty liver
 22 September 2016 
Predicting small-bowel Crohn’s disease
 22 September 2016 
Colectomy outcomes for ulcerative colitis
 22 September 2016 
Technology vs intervention for weight loss
 21 September 2016 
Employment status and IBD
 21 September 2016 
Cardiopulmonary exercise testing in liver transplant candidates
 21 September 2016 
Patients vs providers on nutrition in IBD
 20 September 2016 
Improving healthcare systems for viral Hepatitis
 20 September 2016 
GI benefits of COX-2 selective inhibitors
 20 September 2016 
Predicting relapse in Crohn's
 19 September 2016 
Prevalence of esophageal cancer in Barrett's
 19 September 2016 
Fecal microbiota transplantation and CDI in IBD
 19 September 2016 
Antibiotic resistance in Helicobacter pylori
 16 September 2016 
Low-residue diet before colonoscopy and bowel cleansing
 16 September 2016 
Genome-wide association in gastric cancer
 16 September 2016 
H. pylori in children with asthma
 15 September 2016 
Improving survival in cholangitis-associated septic shock
 15 September 2016 
Colorectal cancer survival and hospital volumes
 15 September 2016 
Primary sclerosing cholangitis and IBD
 14 September 2016 
Intestinal malabsorption and olmesartan
 14 September 2016 
Infection reduction strategy after colorectal resection
 14 September 2016 
Predicting long-term infliximab use in Crohn's
 13 September 2016 
Predicting survival in refractory celiac disease
 13 September 2016 
Cancer risk stratification in Barrett’s
 13 September 2016 
Screening vs non-screening colonoscopy
 12 September 2016 
Screening in familial colorectal cancer
 12 September 2016 
Metformin improves survival in pancreatic ductal cancer
 12 September 2016 
Consent guidelines for GI endoscopy procedures
 09 September 2016 
Development of IBS
 09 September 2016 
Safe and effective treatment for NASH
 09 September 2016 
Scale for stool measurement in diarrhea-IBS
 08 September 2016 
Prognostic factors for infliximab in Crohn's
 08 September 2016 
Chronic Hep B vs chronic Hep C and mortality
 08 September 2016 
Hematological malignancies in IBD
 07 September 2016 
IBD relapse during pregnancy
 07 September 2016 
New treatments for ulcerative colitis
 07 September 2016 
Alternative to nucleic acid testing in HCV
 06 September 2016 
EHealth technologies in IBD
 06 September 2016 
Endoscopy clinic no-shows
 06 September 2016 
Risk of infection after elective colorectal surgery
 05 September 2016 
Esophageal impedance monitoring
 05 September 2016 
Biomarker for IBD and GI cancer
 05 September 2016 
Family history and IBD clinical course
 02 September 2016 
Dietary carbohydrate intake, insulin resistance and GERD 
 02 September 2016 
Postpolypectomy bleeding in the colorectum
 02 September 2016 
Postop recurrence of Crohn's
 01 September 2016 
Prognostic test for liver transplants
 01 September 2016 
Recovery after colorectal surgery in elderly patients
 01 September 2016 
Obesity and post-ERCP pancreatitis

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2016 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us