Help
Subscribe


All of GastroHep is now free access! - Click here to register Read For FREE - Our full range of review articles
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Guido Tytgat Profile of Pete Peterson Profile of Peter Cotton Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Oral anti-viral agents influence the incidence of hepatocellular carcinoma in Hep B

The latest issue of the Alimentary Pharmacology & Therapeutics investigates the impact of oral anti-viral agents on the incidence of hepatocellular carcinoma in chronic hepatitis B.

News image

There are 5 oral nucleos(t)ide analogues available to treat chronic hepatitis B. 
With the availability of newer agents, their efficacy on incidence of hepatocellular carcinoma is not well described.
 
Dr Singal and colleagues determined the efficacy of oral anti-viral agents in reducing hepatocellular carcinoma risk in relationship with other known factors.
 
Published studies of at least 20 chronic hepatitis B patients treated with an oral anti-viral agent and followed for 2 years were analyzed for incidence of hepatocellular carcinoma per 100 person years follow-up.
The research team noted that pooled homogeneous data from 6 studies showed lamivudine treatment to reduce hepatocellular carcinoma risk by 51% compared with no treatment. 
The hepatocellular carcinoma incidence was 1.3 per 100 person years
Alimentary Pharmacology & Therapeutics

Pooled data from 49 studies of 10,025 treated patients showed a hepatocellular carcinoma incidence of 1.3 per 100 person years, independent of the agent used. 

 
The doctors found that the patient age 50 years and hepatitis B virus-DNA detectability at hepatocellular carcinoma diagnosis increased risk of hepatocellular carcinoma by 2-fold with a 10-fold higher risk among patients with cirrhosis compared with chronic hepatitis. 
 
The team showed patient age, study location and type of study contributed to heterogeneity.
 
Dr Singal's team concluded, "Lamivudine treatment significantly reduces the incidence of hepatocellular carcinoma compared with no treatment." 
 
"However, hepatocellular carcinoma still develops at a rate of 1.3 per 100 patient years in chronic hepatitis B patients receiving an oral anti-viral agent." 
 
"This finding highlights the need for continued hepatocellular carcinoma surveillance, particularly in chronic hepatitis B patients with inadequate viral suppression, older age and cirrhosis."

Aliment Pharmacol & Ther 2013:38(2): 98–106
01 July 2013

Go to top of page Email this page Email this page to a colleague

 04 March 2015

Advanced search
 04 March 2015 
Progression of Barrett's
 04 March 2015 
Multidisciplinary management of rectal cancer
 04 March 2015 
Management of IBD
 03 March 2015 
Risk of anastomotic leak after colectomy
 03 March 2015 
GI bleeding in chronic kidney disease patients on aspirin
 03 March 2015 
EPHX1 polymorphism and esophageal cancer risk
 02 March 2015 
Liver disease in patients awaiting liver transplant
 02 March 2015 
Genes and early diagnosis of IBD
 02 March 2015 
Assessment of GERD
 27 February 2015 
Obesity and weight-loss therapy
 27 February 2015 
MRE performance in staging liver fibrosis
 27 February 2015 
Bleeding in diverticulosis
 26 February 2015 
Familial colorectal cancer risk and primary cancer
 26 February 2015 
Herbal products and the liver
 26 February 2015 
Questionnaires for GERD
 25 February 2015 
Exercise and NAFLD
 25 February 2015 
IBD in Korea
 25 February 2015 
Immunosuppressive therapy and T. whipplei
 24 February 2015 
Clinical trials in pediatric IBD
 24 February 2015 
Reducing health care costs in IBD
 24 February 2015 
GI bleeding after anticoagulation interruption
 23 February 2015 
Visceral abdominal obesity and IBS
 23 February 2015 
Crohn's outcomes with infliximab
 23 February 2015 
Intestinal microbiota and celiac disease
 20 February 2015 
H. pylori eradication
 20 February 2015 
Antiviral treatment and Hep C outcomes
 20 February 2015 
C. diff testing in IBD
 19 February 2015 
Intestinal microbiota in IBS
 19 February 2015 
Peptic ulcer bleeding mortality in liver disease
 19 February 2015 
Fecal microbial transplant in active Crohn's disease
 18 February 2015 
Genetic testing and GI cancers
 18 February 2015 
Placebo analgesia in functional abdominal pain
 18 February 2015 
Successful Hep C virus therapy
 17 February 2015 
Quality measures and colonoscopist selection
 17 February 2015 
Global incidence of esophageal cancer
 17 February 2015 
Anti-viral treatment and survival in Hep C
 16 February 2015 
Saliva for the diagnosis of GERD
 16 February 2015 
H pylori eradication therapy
 16 February 2015 
Medical marijuana for digestive disorders
 13 February 2015 
Prevalence of microscopic colitis
 13 February 2015 
Beta-blockers in cirrhosis
 13 February 2015 
Liver disease and peptic ulcer bleeding
 12 February 2015 
Liver disease in chronic Hep C
 12 February 2015 
Patient-reported outcomes in Hep C
 12 February 2015 
Patients’ colonoscopist selection
 11 February 2015 
Hepatic decompensation in Hep C cirrhosis
 11 February 2015 
Guidelines for the diagnosis of hepatocellular carcinoma
 11 February 2015 
NAFLD and CVD
 10 February 2015 
Percutaneous endoscopic gastrostomy
 10 February 2015 
Factors that influence hepatic steatosis
 10 February 2015 
Gene variants and Crohn's susceptibility
 09 February 2015 
Factors that influence gallstone surgery
 09 February 2015 
Factors associated with increased mortality in cirrhosis
 09 February 2015 
Use of immunomodulators in IBD
 06 February 2015 
Colorectal cancer risk in IBD
 06 February 2015 
H. pylori and peptic ulcer bleeding
 06 February 2015 
IBS and somatization
 05 February 2015 
GERD, dyspepsia and IBS symptoms
 05 February 2015 
Thalidomide and refractory Crohn's
 05 February 2015 
Quality of life in Crohn's after antitumor necrosis factor agents

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2015 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us