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News

Comparison of different commercial Helicobacter pylori serological kits

A study in this month's issue of Helicobacter compares the performance of 29 commercial Helicobacter pylori serological kits

News image

Serology is a noninvasive diagnostic method for the detection of Helicobacter pylori infection.

Many commercial kits are now on the market.

It is necessary to assess their performances to help the user to choose the most appropriate.

Dr Christophe Burucoa and colleagues from France evaluated the performances of 29 commercial serological tests detecting antibodies to Helicobacter pylori using sera from 108 patients prospectively selected from gastroenterology departments of five French hospital centers.

These patients were infected or uninfected by H. pylori, or had doubtful results, according to the gold standard.

The doctors evaluated tests by determining the usual parameters of performance: sensitivity, specificity, positive predictive value, negative predictive value, and accuracy.

Up to 4 of the 17 enzyme-linked immunosorbent assay tests presented excellent results
Helicobacter

The team of researchers found that, depending on the type of analysis, 4 or 2 of the 17 enzyme-linked immunosorbent assay tests presented excellent results, with 5 performance parameters above 90%.

Calculation of the Youden index allowed to show significantly better performances for 1 of the 4 tests.

Performances of the 12 near-patient tests were lower with accuracies 90% for all except one test.

Dr Burucoa's team concluded, "These data should help the users to choose the kit the most appropriate to their goals."

Helicobacter 2013:18(3) :169-179
24 June 2013

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