Dr White and colleagues examined the association between serum vitamin D levels and advanced liver disease in a multiethnic US cohort of HCV patients, and account for dietary and supplemental intake.
The research team measured serum 25-hydroxyvitamin D levels, and used FibroSURE-ActiTest to assess hepatic pathology in a cohort of HCV-infected male veterans.
The research team estimated and adjusted for daily intake of vitamin D from diet using a Dietary History Questionnaire, and dispensed prescriptions prior to study enrolment.
The team used race-stratified logistic regression analyses to evaluate the relationship between serum vitamin D levels, and risk of advanced fibrosis, and advanced inflammation.
|African Americans with insufficient levels had more than 2-fold excess risk of advanced inflammation|
|Alimentary Pharmacology & Therapeutics|
A total of 163 African American, and 126 White non-Hispanics were studied.
The team found that about 44% of African Americans, and 15% of Whites were vitamin D deficient or insufficient.
The team observed that 4% of African Americans, and 9% of White patients had an elevated level.
Among African Americans, patients with elevated serum vitamin D levels had significantly higher odds of advanced fibrosis than those with normal levels.
In contrast, the team noted that African Americans with insufficient or deficient levels had more than 2-fold excess risk of advanced inflammation.
Among White males there was no association between vitamin D levels and advanced fibrosis or inflammation risk.
Dr White's team concludes, "We observed potential differences in the association between vitamin D levels, and degree of HCV-related hepatic fibrosis between White and African American males."
"Additional research is necessary to confirm that high serum vitamin D levels may be associated with advanced fibrosis risk in African American males, and to evaluate whether racial differences exist in HCV-infected females."