There is suggestive but sparse evidence that dyslipidemia is associated with colorectal neoplasms.
Dr Moon Hee Yang from Korea investigated the association of serum lipid and apolipoprotein concentrations with the prevalence of colorectal adenomas.
The team performed a cross-sectional study of 19,281 consecutive participants aged 40–79 years undergoing screening colonoscopy at the Center for Health Promotion of the Samsung Medical Center in Korea from 2006 to 2009.
The research team identified 5,958 participants with colorectal adenomas, including 5,504 with non-advanced adenomas and 454 with advanced adenomas.
The researchers compared the adjusted relative prevalence ratios between the fourth and the first quartiles of serum triglycerides, which were 1.35 for non-advanced adenomas, and 1.45 for advanced adenomas.
|Higher levels of HDL-C were associated with a 12% higher prevalence of non-advance adenoma|
|American Journal Of Gastroenterology|
Higher levels of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-1 were significantly associated with 12%, and 17% higher prevalence of non-advanced adenoma.
The doctors examined that there was also a non-significant association between higher levels of low-density lipoprotein cholesterol and apolipoprotein B with higher prevalence of advanced adenoma.
There was no association between total cholesterol levels with colorectal adenoma.
Dr Yang's team commented, "In this large cross-sectional study, higher levels of serum triglycerides were significantly associated with an increasing prevalence of both non-advanced and advanced colorectal adenomas, while higher levels of ApoA-1 and HDL cholesterol were significantly associated with an increasing prevalence of non-advanced adenomas."