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News

National rates of H pylori recurrence are correlated with human development index

National rates of Helicobacter pylori recurrence are significantly and inversely correlated with human development index, reports May's issue of the Alimentary Pharmacology & Therapeutics.

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Helicobacter pylori infection is a worldwide threat to human health with recurrence rates that vary widely.

The precise correlation between H. pylori recurrence and socioeconomic development has not been determined.

Dr Yan and colleagues from China determined H. pylori recurrence rates after successful eradication and their association with socioeconomic development metrics.

Bibliographical searches were performed in the MEDLINE database.

The doctors reviewed all results, filtered by inclusion criteria, extracted primary results to calculate H. pylori recurrence rates and calculated national Human Development Index (HDI) values for the periods during which the studies were conducted.

Recurrence rate was 3% per patient-year after eradication therapy
Alimentary Pharmacology & Therapeutics

The researchers found that 1226 cases of H. pylori recurrence in 77 eligible studies were observed in 43,525 follow-up patient-years after successful eradication therapy, giving a recurrence rate of 3% per patient-year.

The research team examined that H. pylori recurrence rate was inversely correlated with the national Human Development Index on linear and weighted least square regression analysis.

Countries with very high Human Development Index had a mean recurrence rate significantly lower than that of high, medium, and low Human Development Index countries.

Dr Yan's team commented, "Less-developed areas, as measured by Human Development Index, are more likely to have high H. pylori recurrence rates."

"A different approach to follow-up after H. pylori eradication is needed in developing countries where reinfection is highly prevalent, paying special attention to sources of reinfection and high-risk groups."

Aliment Pharmacol Ther 2013: (37)10: 963-968
15 May 2013

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