Inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis, is a systemic disorder that predominantly affects the bowels but is also associated with venous thromboembolism.
Dr Yuhara and colleagues from California, USA provided a quantitative assessment of the association of Inflammatory bowel disease with venous thromboembolism risk.
In addition, the team explored the possible sources of heterogeneity in the current literature, and conducted a meta-analysis of case–control and cohort studies.
The team identified studies by a literature search of the PubMed and Scopus databases for English language studies.
|Relative risks for deep venous thromboembolism in subjects with IBD was 2.2|
|Alimentary Pharmacology & Therapeutics|
The team of doctors performed several subgroup analyses to explore potential study heterogeneity and bias.
The researchers found 11 studies that met the inclusion criteria.
The research team observed that the summary relative risks for deep venous thromboembolism and pulmonary embolism comparing subjects both with and without Inflammatory bowel disease was 2.2.
After adjusting for obesity and smoking, summary relative risks near 2 were seen for venous thromboembolism in both ulcerative colitis, and Crohn's disease patients.
Dr Yuhara's team concluded, "This meta-analysis showed that inflammatory bowel disease is associated with an approximately two-fold increase in the risk of venous thromboembolism."