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News

Revised European guidelines for the clinical management of Lynch syndrome

The latest issue of Gut reports recommendations by a group of European experts for the clinical management of Lynch syndrome.

News image

Lynch syndrome is characterized by the development of colorectal cancer, endometrial cancer and various other cancers, and is caused by a mutation in one of the mismatch repair genes, including MLH1, MSH2, MSH6 or PMS2.

In 2007, a group of European experts published guidelines for the clinical management of Lynch syndrome.

Dr Hans Vasen from The Netherlands reported that since then, substantial new information has become available necessitating an update of the guidelines.

In 2011 and 2012 workshops were organized in Palma de Mallorca.

The doctors reported that a total of 35 specialists from 13 countries participated in the meetings.

The first step was to formulate important clinical questions.

35 specialists from 13 countries participated in the meetings
Gut

The team of doctors performed a systematic literature search using the Pubmed database, and manual searches of relevant articles.

During the workshops the outcome of the literature search was discussed in detail.

Dr Vasen's team concluded, "The guidelines described in this paper may be helpful for the appropriate management of families with Lynch syndrome."

"Prospective controlled studies should be undertaken to improve further the care of these families."

Gut 2013;62:812-823 doi:10.1136/gutjnl-2012-304356
08 May 2013

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