In gastro-esophageal reflux disease (GERD), heartburn responds well to acid suppression, but regurgitation is a common cause of incomplete treatment response.
Dr Kahrilas and colleagues investigated the prevalence and burden of persistent, frequent regurgitation in primary care patients with gastro-esophageal reflux disease treated with acid suppression.
The research team analyzed observational data from 134 sites across 6 European countries in patients diagnosed with gastro-esophageal reflux disease.
The research team noted that within 3 months of the index visit, symptoms were assessed using the Reflux Disease Questionnaire, and their impact on sleep and work productivity with the Quality of Life in Reflux and Dyspepsia questionnaire and the Work Productivity and Activity Impairment Questionnaire, respectively.
Patients provided information on concomitant over-the-counter gastro-esophageal reflux disease medication use.
The doctors found that persistent, frequent regurgitation was reported by 13% of gastro-esophageal reflux disease patients with no heartburn on acid suppression.
The team noted that the prevalence was very similar for patients with up to 2 days/week of ongoing mild heartburn.
|Frequent regurgitation was reported by 13% of GERD patients with no heartburn |
|Alimentary Pharmacology & Therapeutics|
Among patients without heartburn, sleep disturbance of any type was reported by 51% to 60% with persistent, frequent regurgitation, compared with 38% to 51%, and 14% to 19% of those with less frequent or no regurgitation respectively.
Persistent, frequent regurgitation was associated with increased use of over-the-counter medication and more hours of work missed, whether mild, infrequent heartburn was present or not.
Dr Kahrilas's team commented "Frequent regurgitation, which persisted in 12% to 13% of patients with no or infrequent, mild heartburn on acid suppression, negatively affected sleep and work productivity, and increased use of over the counter medication."
"Persistent, frequent regurgitation is problematic for primary care patients with gastro-esophageal reflux disease."