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Early marker of H. pylori-infected patients at risk of gastric cancer

The corpus-predominant gastritis index may serve as an early marker of Helicobacter pylori-infected patients at risk of gastric cancer, reports a study in the latest issue of Alimentary Pharmacology & Therapeutics.

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To eradicate Helicobacter pylori before the occurrence of precancerous changes is important to prevent gastric carcinogenesis.

Dr Tsai and colleagues validated whether the corpus-predominant gastritis index can serve as an early marker to identify the H. pylori-infected patients at risk of gastric carcinogenesis.

The team enrolled 188 subjects, including 43 noncardiac gastric cancer patients, 63 of their first-degree relatives and 82 sex- and age-matched duodenal ulcer patients as controls.

All received endoscopy to provide topographic gastric specimens to test for H. pylori infection and its related histological features, translated into the operative link on gastritis assessment, operative link on gastric intestinal metaplasia assessment stages, and the presence of corpus-predominant gastritis index.

The researchers assessed spasmolytic polypeptide-expressing metaplasia by immunohistochemistry staining of trefoil factor 2.

Gastric cancer patients had higher prevalence of corpus-predominant gastritis index and perative link on gastric intestinal metaplasia assessment stage II–IV, but not operative link on gastritis assessment stage II–IV, than the controls.

Corpus-predominant gastritis index increased the risk of spasmolytic polypeptide-expressing metaplasia
Alimentary Pharmacology & Therapeutics

The team of doctors noted that in patients with the combined presence of corpus-predominant gastritis index, and perative link on gastric intestinal metaplasia assessment stage II–IV, the risk of gastric cancer increased to 9.8.

The first-degree relatives of the gastric cancer patients had a higher rate of the presence of corpus-predominant gastritis index, but not operative link on gastritis assessment or perative link on gastric intestinal metaplasia assessment stage II–IV than the duodenal ulcer controls.

Of the first-degree relatives, the presence of corpus-predominant gastritis index increased the risk of spasmolytic polypeptide-expressing metaplasia.

Dr Tsai's team commented, "The corpus-predominant gastritis index, which is highly correlated to spasmolytic polypeptide-expressing metaplasia, may serve as an early marker to identify the H. pylori-infected patients at a higher risk of gastric cancer."

Aliment Pharmacol Ther 2013: 37(10): 969-978
02 May 2013

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