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 24 May 2016

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News

National rates of H. pylori recurrence are associated with human development index

A study published ahead of print in the Alimentary Pharmacology & Therapeutics reports that national rates of Helicobacter pylori recurrence are significantly and inversely correlated with human development index.

News image

Helicobacter pylori infection is a worldwide threat to human health with recurrence rates that vary widely.

The precise correlation between H. pylori recurrence and socioeconomic development has not been determined.

Dr Yan and colleagues determined H. pylori  recurrence rates after successful eradication and their association with socioeconomic development metrics.

Bibliographical searches were performed in the MEDLINE database.

The reporters assessed that they reviewed all results, filtered by inclusion criteria, extracted primary results to calculate H. pylori recurrence rates, and calculated national Human Development Index values for the periods during which the studies were conducted.

The research team observed 1226 cases of H. pylori recurrence in 77 eligible studies in 43 525  follow-up patient-years after successful eradication therapy, giving a recurrence rate of 2% per patient-year.

The research team examined that H. pylori recurrence rate was inversely correlated with national Human Development Index on linear and weighted least square regression analysis.

The calculated pooled gastric cancer incidence-rate was about 0.3% per person-years
Alimentary Pharmacology & Therapeutics

Countries with very high Human Development Index had a mean recurrence rate significantly lower than that of high, medium, and low Human Development Index countries.

Dr Yan's team concluded, "Less-developed areas, as measured by Human Development Index, are more likely to have highH. pylori recurrence rates."

"A different approach to follow-up after H. pylori eradication is needed in developing countries where reinfection is highly prevalent, paying special attention to sources of reinfection and high-risk groups."

Aliment Pharmacol Ther 2013: 37(10): 963-968
01 May 2013

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