Dr Jeff Turner and colleagues determined the differences between in-situ, prefixation and postfixation colorectal polyp measurements, their clinical impact upon determining adenoma surveillance intervals, and to compare postfixation measurements using 3 different devices.
A prospective study of 107 colorectal polyps resected from 65 consecutive patients undergoing colonoscopy as part of the Bowel Cancer Screening Programme was undertaken.
The team measured polyps in situ, prefixation and using 3 measurement devices postfixation in formalin.
Prefixation ruler measurements were significantly higher than in-situ and postfixation ruler measurements.
The research team found no significant difference between in-situ and postfixation ruler measurements, although in-situ measurements were more variable.
In-situ measurements also generated more variation in surveillance intervals than postfixation measurements.
|Prefixation ruler measurements were higher than in-situ ruler measurements|
|European Journal of Gastroenterology & Hepatology |
The doctors observed no significant difference was seen between measurements obtained by the three different devices postfixation.
Dr Turner's team commented, "This study provides evidence supporting the use of postfixation polyp size measurements as advised by recent European pathology colorectal cancer screening recommendations."
"In the absence of a clinically significant difference between measurement devices, we advise the ruler to be used as a standard for postfixation measurements because of its widespread availability."