Psychiatric comorbidity is common in Crohn's disease and ulcerative colitis.
Inflammatory bowel disease-related surgery or hospitalizations represent major events in the natural history of the disease.
Dr Ashwin Ananthakrishnan and colleagues examined whether there is a difference in the risk of psychiatric comorbidity following surgery in Crohn's disease and ulcerative colitis.
The team used a multi-institution cohort of Inflammatory bowel disease patients without a diagnosis code for anxiety or depression preceding their Inflammatory bowel disease-related surgery or hospitalization.
The research team assessed that demographic-, disease-, and treatment-related variables were retrieved.
Multivariate logistic regression analysis was performed to individually identify risk factors for depression and anxiety.
The team of doctors evaluated a total of 707 Crohn's disease, and 530 ulcerative colitis patients who underwent bowel resection surgery and did not have depression before surgery.
|The risk of depression 5 years after surgery was 16% in Crohn's |
|American Journal of Gastroenterology|
The risk of depression 5 years after surgery was 16% and 11% in Crohn's disease and ulcerative colitis patients, respectively.
The researchers found no difference in the risk of depression following surgery in the Crohn's disease and ulcerative colitis patients.
Female gender, comorbidity, immunosuppressant use, perianal disease, stoma surgery, and early surgery within 3 years of care predicted depression after Crohn's disease surgery.
The team observed that only the female gender and comorbidity predicted depression in ulcerative colitis patients.
Only 12% of the Crohn's disease cohort had 4 risk factors for depression, but among them nearly 44% subsequently received a diagnosis code for depression.
Dr Ananthakrishnan's team commented, "Inflammatory bowel disease-related surgery or hospitalization is associated with a significant risk for depression and anxiety, with a similar magnitude of risk in both diseases."