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Childhood migraine is associated with a history of infantile colic

A study in this week's issue of the Journal of the American Medical Association investigates the association between childhood migraine and history of infantile colic.

News image

Infantile colic is a common cause of inconsolable crying during the first months of life and has been thought to be a pain syndrome.

Migraine is a common cause of headache pain in childhood.

Whether there is an association between these 2 types of pain in unknown.

Dr Silvia Romanello and colleagues investigated a possible association between infantile colic and migraines in childhood.

A case-control study of 208 consecutive children aged 6 to 18 years presenting to the emergency department and diagnosed as having migraines in 3 European tertiary care hospitals between 2012 and 2012.

Early treatment was more cost-effective
Journal of the American Medical Association

The control group was composed of 471 children in the same age range who visited the emergency department of each participating center for minor trauma during the same period.

A structured questionnaire identified personal history of infantile colic for case and control participants, confirmed by health booklets.

A second study of 120 children diagnosed with tension-type headaches was done to test the specificity of the association.

The research team's main outcomes and measures included difference in the prevalence of infantile colic between children with and without a diagnosis of migraine.

Children with migraine were more likely to have experienced infantile colic than those without migraine, either migraine without aura, or migraine with aura.

The researchers did not observe this association for children with tension-type headache.

Dr Romanello's team concludes, "The presence of migraine in children and adolescents aged 6 to 18 years was associated with a history of infantile colic."

"Additional longitudinal studies are required."

JAMA 2013; 309(15): 1607-1612
18 April 2013

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