Inflammatory bowel disease is a chronic inflammatory disorder.
Systemic inflammation increases the risk of atherosclerosis and ischemic heart disease.
Dr Christine Rungoe and colleagues from Denmark examined the impact of Inflammatory bowel disease, including its duration and treatment, on the risk of ischemic heart disease.
In a nationwide population-based cohort of 4.6 million Danes aged 15 years, the team compared people diagnosed with Inflammatory bowel disease during 1997–2009 with Inflammatory bowel disease-free individuals.
The research team identified subjects with ischemic heart disease in the National Patient Register.
The team estimated the incidence rate ratios for ischemic heart disease with 95% CI with adjustment for age, gender, socioeconomic status, calendar year and use of drugs for comorbidities.
|After IBD diagnosis, the risk of ischemic heart disease was 1.2|
The team of doctors noted a markedly increased risk of ischemic heart disease within the first year after Inflammatory bowel disease diagnosis.
During 1–13 years of follow-up after Inflammatory bowel disease diagnosis, the risk of ischemic heart disease was 1.2.
The researchers found that the risk of ischemic heart disease was lower among patients with Inflammatory bowel disease using 5-aminosalicylic acids than among non-users, in particular among oral corticosteroid users, used as a proxy for disease severity.
Likewise patients treated surgically or with thiopurines and tumor necrosis factor α antagonists tended to have reduced incidence rate ratios for ischemic heart disease.
Dr Rungoe's team commented, "The risk of ischemic heart disease was highest in the first year after Inflammatory bowel disease diagnosis, possibly owing to ascertainment bias."
"The increased long-term risk of ischemic heart disease may be related to chronic inflammation, and interventions reducing the inflammatory burden may attenuate this risk."