Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 30 April 2016

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Colorectal cancer screening interval after negative colonoscopy

The latest issue of Surgical Endoscopy investigaates the correct screening interval for colorectal cancer after negative colonoscopy.

News image

Despite the high sensitivity of screening colonoscopy, polyps and cancers can still go undetected.

With the polyp-to-cancer transformation cycle averaging 7–10 years, present guidelines recommend repeat colonoscopy within 10 years after negative screening.

However, not all colorectal malignancies follow this decade-long progression.

Dr Steven Nakao and colleagues evaluated the incidence and pathology of colorectal cancers following a previous negative screening colonoscopy.

Records of patients who underwent a colectomy at our institution, from 1998 to 2009, were reviewed retrospectively.

The researchers reported that a total of 1,784 patient records were screened using exclusion criteria for inclusion in this study.

Group 1 included patients with a negative colonoscopy within the previous 5 years.

Group 2 included patients without a previous colonoscopy or with a previous colonoscopy more than 5 years prior.

Group 1 patients were evaluated by colonoscopy for anemia, diverticulitis, signs of obstruction, and bleeding.

Age, tumor location, operation performed, and pathology findings were recorded.

The team of researchers assessd that the χ2 test and paired t test were used for statistical analysis.

A total of 233 patients were included in this study.

18% developed colorectal cancer
Surgical Endoscopy

Group 1 contained 43 patients with a mean age of 73 years.

Group 2 had 190 patients with a mean age of 68 years.

The team of doctors noted that group 1 consisted of 18 male and 25 female patients, and Group 2 included 94 male and 96 female patients.

Both groups were further classified into age categories including 50 years, 50–80 years, and 80 years.

The research team noted that 18% of the total study population had newly discovered colorectal cancer within a 5-year colonoscopy screening period.

There were no significant differences in the distribution of the T and N stages between the 2 groups, and no statistically significant differences when the rate of lymphovascular invasion and perineural invasion were compared.

Within 5 years, 18% developed colorectal cancer.

Dr Nakao's team commented "Most of these malignancies were found within the 50–80-year age group and located predominantly in the right colon and distally in the sigmoid and rectum."

"While distal cancers may be visualized by flexible sigmoidoscopy, those located more proximally may be missed, necessitating the need for a full colonoscopy."

"Although staging was similar between the two groups, Group 1 tumors were less aggressive despite having appeared within 5 years."

"As a result of our incidence of colorectal cancer within a 5-year interval, a shorter period for routine colonoscopy may be considered."

Surgical Endoscopy 2013: 3(27): 768-773
01 April 2013

Go to top of page Email this page Email this page to a colleague

 29 April 2016 
Crohn's disease associated genes
 29 April 2016 
Simvastatins and survival in cirrhosis
 29 April 2016 
HCV infection in Baby Boomers with Medicare
 28 April 2016 
Diarrheal diseases in children
 28 April 2016 
Racial disparities in survival from colon cancer
 28 April 2016 
Birth outcomes in women with IBD receiving assisted reproduction
 27 April 2016 
Dust mite and human GI tract
 27 April 2016 
Celiac disease in adults
 27 April 2016 
Ultra-short celiac disease
 26 April 2016 
Guidelines for nutrition therapy in hospitalized patients
 26 April 2016 
IBS and microscopic colitis
 26 April 2016 
Polyp detection during colonoscopy
 25 April 2016 
Estrogen deficiency and fibrosis risk in women with NAFLD
 25 April 2016 
Acceptance of Liver transplant center organ offers
 25 April 2016 
Abrupt interruption of beta-blockers in cirrhosis 
 22 April 2016 
Novel method to regenerate the esophagus
 22 April 2016 
Relapse after antiviral treatment in Hep B
 22 April 2016 
Microscopic colitis with NSAIDs and PPIs
 11 April 2016 
Admissions times and outcomes for ERCP cholangitis
 11 April 2016 
Infliximab vs adalimumab in ulcerative colitis
 11 April 2016 
H. pylori in treatment-naïve children
 08 April 2016 
Endoscopic treatment of Crohn's strictures
 08 April 2016 
Nutrition therapy in the hospitalized patient
 08 April 2016 
H.pylori effects on pediatric gastric mucosa
 07 April 2016 
CVD changes after TIPSS
 07 April 2016 
HBV during immunosuppressive therapies
 07 April 2016 
Transanal mesorectal resection for rectal cancer
 06 April 2016 
Adherence to colorectal cancer screening strategies
 06 April 2016 
Duodenal bulb biopsies in childhood celiac disease diagnosis
 06 April 2016 
Lymph node metastasis in early gastric cancer
 05 April 2016 
IBS in the US military
 05 April 2016 
Changes in blood flow in cirrhosis
 05 April 2016 
Colorectal cancer risk with serrated polyps
 04 April 2016 
Noninvasive diagnosis of celiac disease
 04 April 2016 
Metallic vs plastic stents for benign biliary strictures
 04 April 2016 
Adherence to quality indicators improves clinical outcomes in ascites
 01 April 2016 
Prognosis after colorectal cancer resection with peritoneal metastasis
 01 April 2016 
Colorectal cancer risk with non-malignant colonoscopy findings
 01 April 2016 
Intensive enteral nutrition and severe alcoholic hepatitis
 31 March 2016 
Anesthesia services during colonoscopy
 31 March 2016 
Alcohol and glucose tolerance in NAFLD
 31 March 2016 
Management of Barrett’s esophagus
 30 March 2016 
Depression and symptoms in IBS
 30 March 2016 
Electronic learning system for colon capsule endoscopy
 30 March 2016 
Gastric cancer screening
 29 March 2016 
Statins and survival in esophageal cancer
 29 March 2016 
Infant feeding practices and celiac disease
 25 March 2016 
Medical therapy and neoplasia regression in familial adenomatous polyposis
 25 March 2016 
Medical therapy compliance and ulcerative colitis recurrence
 25 March 2016 
Predicting outcomes of drug-induced acute liver failure
 24 March 2016 
Thrombocytopenia and multi-organ system failure in acute liver failure
 24 March 2016 
Patients with ulcerative colitis and their concerns
 24 March 2016 
Prediction of relapses in IBD
 23 March 2016 
Thiopurine therapy in IBD
 23 March 2016 
Early colonoscopy for lower GI bleeds
 23 March 2016 
Treatment with immunomodulators and biologics in ulcerative colitis
 22 March 2016 
Bile acid diarrhea
 22 March 2016 
Psoriasis induced by anti-TNF therapy in IBD
 22 March 2016 
Predicting mortality in acute liver failure
 21 March 2016 
Gut microbiota and risk of pneumococcal pneumonia

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2016 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us