Serological markers such as anti-neutrophil cytoplasmic antibody (ANCA) and anti-Saccharomyces cerevisiae antibody (ASCA) may be associated with pouchitis after ileal pouch-anal anastomosis (IPAA).
Dr Pardi and colleagues from Minnesota, USA performed a systematic review with meta-analysis of studies evaluating the association of ANCA and ASCA status with risk of acute and chronic pouchitis after IPAA.
The team searched multiple databases for studies reporting ANCA and/or ASCA status along with risk of acute or chronic pouchitis after IPAA in adults with ulcerative colitis.
The researchers abstracted odds ratio or raw data from the individual studies to calculate summary odds ratio estimates with 95% confidence intervals using random-effects model.
The team identified 8 studies reporting 184 cases of acute pouchitis, and 6 studies reporting 151 cases of chronic pouchitis were included.
The odds of chronic pouchitis were 76% higher in ANCA-positive patients than ANCA-negative.
ASCA-positivity was not associated with the risk of chronic pouchitis.
The research team observed that neither ANCA nor ASCA-positivity were associated with the risk of acute pouchitis.
Dr Pardi's team commented, "The risk of chronic pouchitis after IPAA is higher in ANCA-positive patients, but the risk of acute pouchitis is unaffected by ANCA status."
"ASCA status was not associated with the risk of acute or chronic pouchitis."
"This information may be used to counsel ulcerative colitis patients regarding their risk of pouchitis after IPAA."