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 27 June 2016

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News

Infliximab influences mucosal healing in ulcerative colitis

A study published ahead of print in the Alimentary Pharmacology & Therapeutics examines the impact of mucosal healing on long-term outcomes in patients with ulcerative colitis when treated with infliximab.

News image

Mucosal healing can be achieved with infliximab.
 
Dr Laharie and colleagues from France assessed the impact of mucosal healing on long-term outcomes in patients with ulcerative colitis when treated with infliximab beyond 1 year.
 
All consecutive adult patients with refractory ulcerative colitis receiving maintenance treatment with infliximab in 5 French referral centres were analyzed retrospectively.

Only patients who had endoscopic evaluation between 6 and 52 weeks following infliximab initiation were included.

According to their Mayo endoscopic sub-score, patients were categorized into mucosal healing, and no mucosal healing.

48% achieved mucosal healing
Alimentary Pharmacology & Therapeutics

Outcome measures were colectomy and infliximab failure defined by drug withdrawal due to secondary failure among primary responders.
 
Of the 63 patients, 48% achieved mucosal healing.

The median follow-up duration was 27 months.

Colectomy-free survival rates at 12, 24 and 36 months were, respectively, 100%, 96% and 96% in patients with mucosal healing.

The corresponding figures were, respectively, 80%, 65% and 65% in patients without mucosal healing.

By multivariate analysis, mucosal healing was the only factor associated with colectomy-free survival, with an odds ratio of 18.

The team noted that infliximab failure-free survival rates at 12, 24 and 36 months were, respectively, 76%, 69% and 64% in patients with mucosal healing, and 44%, 25% and 21% in those without mucosal healing.
 
Dr Laharie's team commented, "Patients with refractory ulcerative colitis who achieved mucosal healing after infliximab initiation had better long-term outcomes, with significantly less colectomy and less infliximab failure."

Aliment Pharmacol Ther 2013: DOI: 10.1111/apt.12289
25 March 2013

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