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News

Infliximab influences mucosal healing in ulcerative colitis

A study published ahead of print in the Alimentary Pharmacology & Therapeutics examines the impact of mucosal healing on long-term outcomes in patients with ulcerative colitis when treated with infliximab.

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Mucosal healing can be achieved with infliximab.
 
Dr Laharie and colleagues from France assessed the impact of mucosal healing on long-term outcomes in patients with ulcerative colitis when treated with infliximab beyond 1 year.
 
All consecutive adult patients with refractory ulcerative colitis receiving maintenance treatment with infliximab in 5 French referral centres were analyzed retrospectively.

Only patients who had endoscopic evaluation between 6 and 52 weeks following infliximab initiation were included.

According to their Mayo endoscopic sub-score, patients were categorized into mucosal healing, and no mucosal healing.

48% achieved mucosal healing
Alimentary Pharmacology & Therapeutics

Outcome measures were colectomy and infliximab failure defined by drug withdrawal due to secondary failure among primary responders.
 
Of the 63 patients, 48% achieved mucosal healing.

The median follow-up duration was 27 months.

Colectomy-free survival rates at 12, 24 and 36 months were, respectively, 100%, 96% and 96% in patients with mucosal healing.

The corresponding figures were, respectively, 80%, 65% and 65% in patients without mucosal healing.

By multivariate analysis, mucosal healing was the only factor associated with colectomy-free survival, with an odds ratio of 18.

The team noted that infliximab failure-free survival rates at 12, 24 and 36 months were, respectively, 76%, 69% and 64% in patients with mucosal healing, and 44%, 25% and 21% in those without mucosal healing.
 
Dr Laharie's team commented, "Patients with refractory ulcerative colitis who achieved mucosal healing after infliximab initiation had better long-term outcomes, with significantly less colectomy and less infliximab failure."

Aliment Pharmacol Ther 2013: DOI: 10.1111/apt.12289
25 March 2013

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