Dr Patrick Lynch and colleagues from Texas,USA developed a global quantitative tools of the familial adenomatous polyposis colorectal adenoma burden.
The team posted videos on treatment before and after celecoxib for 6 months, to an intranet with an interactive site for scoring.
Global adenoma counts and sizes were scored from videos by using a novel Web-based tool.
Baseline and end-of-study adenoma burden results were summarized by using 5 models.
Correlations between pairs of reviewers were analyzed for each model.
Interobserver agreement was high for all 5 measures of polyp burden.
The research team reported that both polyp count and polyp size had better interobserver agreement than measures based only on polyp count.
|Treatment reduced the polyp burden by these measurements in 70% to 89% of patients|
|Gastrointestinal Endoscopy |
The measure in which polyp counts were weighted according to diameter had the highest interobserver agreement.
Dr Lynch and team conclude, "Treatment reduced the polyp burden by these measurements in 70% to 89% of patients."
"This novel, web-based polyp scoring method provides a convenient and reproducible way to quantify the global colorectal adenoma burden in familial adenomatous polyposis patients and a framework for developing a clinical staging system for familial adenomatous polyposis."