The impact of moderate alcohol consumption on long-term outcomes of chronic hepatitis C infected patients remains controversial.
Dr Younossi and colleagues assessed the impact of moderate alcohol consumption on long-term outcomes of chronic hepatitis C patients using population-based data.
The team obtained from the Third National Health and Nutrition Examination Survey-mortality linked files.
Alcohol consumption was estimated as grams per day.
Multivariate Cox proportional hazards model was utilized to assess the effects of chronic hepatitis C and alcohol consumption on mortality.
A total of 8985 participants were included as the study cohort.
Of these, 218 had chronic hepatitis C.
|Mortality associated with chronic HCV increased with moderate alcohol consumption of 1–19 g per day|
|Alimentary Pharmacology & Therapeutics|
The research team assessed that the follow-up time was 163 months for chronic hepatitis C, and 178 months for controls.
Chronic hepatitis C patients had increased risk for both overall mortality and liver-related mortality.
The team of doctors examined that chronic hepatitis C patients with excessive alcohol consumption had even higher risks for overall mortality and liver-related mortality.
The research team noted that the risk of overall mortality associated with chronic hepatitis C increased with moderate alcohol consumption of 1–19 g per day, and heavy alcohol consumption 30 g per day.
Dr Younossi's team concludes, "Although chronic hepatitis C is associated with increased risks for overall and liver-related mortality, these risks are even higher for patients consuming moderate and excessive amounts of alcohol."