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Increased risk of neoplasms among asymptomatic siblings in colorectal cancer

A study in March's issue of Gastroenterology reports an increased risk of advanced neoplasms among asymptomatic siblings of patients with colorectal cancer.

News image

Colorectal cancer is the second-most common cancer in Hong Kong.

Relatives of patients with Colorectal cancer have an increased risk of colorectal neoplasm.

Dr Siew Ng from Hong Kong assessed the prevalence of advanced neoplasms among asymptomatic siblings of patients with colorectal cancer.

Patients with colorectal cancer were identified from the Prince of Wales Hospital Colorectal cancer Surgery Registry from 2001 to 2011.

The researchers noted that colonoscopies were performed for 374 siblings of patients, and 374 age- and sex-matched siblings of healthy subjects who had normal colonoscopies and no family history of Colorectal cancer.

The research team identified individuals with advanced neoplasms.

The prevalence of advanced neoplasms was 8% among siblings of patients
Gastroenterology

The doctors assessed that the prevalence of advanced neoplasms was 8% among siblings of patients, and 3% among controls.

The prevalence of adenomas larger than 10 mm was higher among siblings of patients than in controls, as was the presence of colorectal adenomas.

The team of researchers detected 6 cancers among siblings of patients, and no cancers were detected in controls.

The prevalence of advanced neoplasms among siblings of patients was higher when their index case was female and had distally located colorectal cancer.

Dr Ng and team commented, "In Hong Kong, siblings of patients with colorectal cancer have a higher prevalence of advanced neoplasms, including colorectal cancer, than siblings of healthy individuals."

"Screening is indicated in this high-risk population."

Gastroenterology 2013: 144(3): 544-550
28 February 2013

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