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News

Obesity influences esophageal function and symptoms of GERD

A study published ahead of print in the Alimentary Pharmacology & Therapeutics examines the effects of obesity on esophageal function, acid exposure and the symptoms of gastro-esophageal reflux disease.

News image

Obese patients have an increased risk of gastro-esophageal reflux disease (GERD).

However, the mechanism underlying this association is uncertain.

Dr Anggiansah and colleagues tested the hypothesis that mechanical effects of obesity on esophageal function increase acid exposure and symptoms.

The team noted that height, weight and waist circumference were measured in patients with typical reflux symptoms referred for manometry and 24 hour ambulatory pH studies.

Symptom severity was assessed by questionnaire.

The doctors reported that the association between obesity, esophageal function, acid exposure and reflux symptoms was assessed.

Physiological measurements were obtained from 582 patients of whom 406 completed symptom questionnaires.

The researchers noted that the prevalence of general obesity was greater in women, however more men had abdominal obesity.

Abdominal obesity is associated with esophageal dysfunction
Alimentary Pharmacology & Therapeutics

Esophageal acid exposure increased with obesity and was associated also with lower esophageal sphincter pressure, reduced abdominal lower esophageal sphincter  length and peristaltic dysfunction.

The doctors reported that univariable regression showed a negative association of weight and waist circumference with both lower esophageal sphincter pressure, and abdominal lower esophageal sphincter  length.

The researchers demonstrated that the effects of increasing weight and waist circumference on esophageal function do not explain increased acid reflux in obese patients.

The researchers found that independent effects of obesity and esophageal dysfunction on acid exposure were present.

Reflux symptoms increased with acid exposure and this association explained increased symptom severity in obese patients.

Dr Anggiansah's team concludes, "Abdominal obesity is associated with esophageal dysfunction, increased acid exposure and reflux symptoms."

"However, this analysis does not support the mechanical hypothesis that the effects of obesity on esophageal function are the cause of increased acid exposure in obese patients."

Aliment Pharmacol Ther 2013: 37(5): 555-569


14 February 2013

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