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News

H pylori is a risk factor for colonic neoplasms

Helicobacter pylori is a risk factor for colonic neoplasms, reports the most recent issue of the American Journal of Gastroenterology.

News image

It has been suggested that Helicobacter pylori constitutes a risk for the development of adenomatous polyps and adenocarcinoma of the colon.

Dr Amnon Sonnenberg and colleagues studied the association between H pylori-positive gastritis and the occurrence of any colonic neoplasm.

From a computerized database of surgical pathology reports, the team selected 156,000 subjects who underwent colonoscopy and esophago-gastro-duodenoscopy with biopsy results from both procedures.

The association between H pylori-positive gastritis and colonic neoplasm became stronger with size of adenomas
American Journal of Gastroenterology

Compared with normal gastric mucosa, H pylori gastritis occurred more frequently among patients with hyperplastic polyps, adenomatous polyps, advanced adenomas, villous adenomas or adenomas with high-grade dysplasia, and adenocarcinomas.

The doctors noted that similarly, the strength of the association between H pylori-positive gastritis and colonic neoplasm increased with size and number of the adenomas.

The association between H pylori gastritis and the occurrence of colonic neoplasm was similar for different locations of the large bowel.

Other gastric conditions etiologically associated with H pylori, such as intestinal metaplasia, adenoma, lymphoma, and adenocarcinoma, were also significantly associated with an increased risk of colonic neoplasm.

Dr Sonneberg's team concludes, "Various forms of gastritis related to H pylori infection confer an increased risk for colonic neoplasm. In the past, when H pylori infection was more prevalent, its attributable risk to the occurrence of colorectal neoplasm may have been quite substantial."

Am J Gastroenterol 2013: 108: 208-215
11 February 2013

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