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News

Variability of fecal calprotectin in quiescent Crohn's disease

The latest issue of the Alimentary Pharmacology & Therapeutics evaluates the intra-individual variability of fecal calprotectin in quiescent Crohn's disease.

News image

Dr Naismith and colleagues determined the degree of this intrapersonal variability in the context of quiescent Crohn's disease.

A single-centre prospective study was undertaken in 143 Crohn's disease patients in clinical remission.

The research team analyzed 3 fecal calprotectin levels from stool samples on consecutive days.

Consistency of fecal calprotectin levels was determined by measuring the intraclass correlation (ICC).

The reliability of detecting a ‘case’ of active inflammation as defined for specific concentrations of fecal calprotectin was measured by the kappa statistic.

The kappa statistic for the reliability of detecting a case as defined by an FC level of 50 μg/g was 0.65
Alimentary Pharmacology & Therapeutics

The research team obtained 98 complete sets of results.

The ICC was 0.8, which represents low variability across samples.

The doctors reported the kappa statistic for the reliability of detecting a case as defined by an FC level of 50 μg/g was substantial at 0.65.

Dr Naismith's team concluded, "Day to day variability of fecal calprotectin is low in our cohort of quiescent Crohn's disease patients and the reliability of defining a ‘case’ is moderately good."

"These data provide reassurance to clinicians using a single calprotectin sample to inform therapeutic strategies in this cohort."

Aliment Pharmacol Ther 2013: DOI: 10.1111/apt.12221
06 February 2013

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