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News

Gastric cancer incidence in pernicious anemia

A study published ahead of print in the Alimentary Pharmacology & Therapeutics investigates gastric cancer incidence in pernicious anemia.

News image

Pernicious anemia has an increased risk for gastric cancer (GC).

It is not established whether pernicious anemia patients need to undergo endoscopic/histological follow-up.

Dr Vannella and colleagues performed a systematic overview of the literature on pernicious anemia and the development of gastric cancer, to estimate the gastric cancer incidence-rate.

According to PRISMA, the team identified studies on pernicious anemia patients reporting the incidence of gastric cancer.

Quality of studies was evaluated using the Newcastle-Ottawa Quality Assessment Scale.

The doctors performed a meta-analysis on annual gastric cancer incidence rates.

The team identified 27 studies that met eligibility criteria.

The research team found that 7 studies were of high, 6 of medium, 10 of low, and 4 of very low quality.

The calculated pooled gastric cancer incidence-rate was about 0.3% per person-years
Alimentary Pharmacology & Therapeutics

The research team examined that gastric cancer incidence-rates ranged from 0% to 0.2% per person-years in 7 American, from 0% to 0.5% in 2 Asiatic, from 0% to 1% in 11 Northern European studies, and from 0% to 0.9% in 7 studies from other European countries.

The incidence-rates of gastric cancer ranged from 0% to 1.2% per person-years in studies which used gastroscopy, and from 0.1% to 0.9% in those based on International Classification of Disease.

The team found that the calculated pooled gastric cancer incidence-rate was 0.3% per person-years.

The research team examined that meta-analysis showed overall gastric cancer relative risk in pernicious anemia as 6.8.

Dr Vanella's team concluded, "This systematic review shows a pooled gastric cancer incidence-rate in pernicious anemia of about 0.3% per person-years, and an estimated nearly 7-fold relative risk of gastric cancer in pernicious anemia patients."

"Further high quality studies are needed to confirm this higher risk."

Aliment Pharmacol Ther 2013: 37(4): 375-382
30 January 2013

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