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 09 February 2016

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News

Survival after the use of sirolimus in liver transplantation for hepatocellular carcinoma

A study published ahead of print in the Alimentary Pharmacology & Therapeutics ivnestigates the recurrence and survival following the use of sirolimus in liver transplantation for hepatocellular carcinoma.

News image

The use of sirolimus-based immunosuppression protocols have been reported to reduce recurrence rates following liver transplantation for hepatocellular carcinoma, although this is still a matter for debate.

Dr Menon and colleagues from the United Kingdom performed a systematic review and meta-analysis of available literature on the usage of sirolimus as an immunosuppressive agent following liver transplantation for hepatocellular carcinoma, with a view to comparing cancer outcomes with the commonly used calcineurin inhibitors

The team's primary outcomes of interest were tumor recurrence rate and recurrence-free survival.

Secondary outcomes were recurrence-related mortality, and overall survival.

The researchers noted that in all, 5 studies met the inclusion criteria.

The 1-year recurrence-free survival was 93% to 96%
Alimentary Pharmacology & Therapeutics

The recurrence rate was lower in sirolimus group in comparison with calcineurin inhibitors.

The doctors found that the 1-, 3- and 5-year recurrence-free survival was 93% to 96%, 82% to 86%, and 79% to 80% for sirolimus group, which was much better in comparison with the calcineurin inhibitors at 70%-78%, 64% to 65%, and 54% to 60%, respectively.

Similarly, 1-, 3- and 5-year overall survival was much better for sirolimus group in comparison with calcineurin inhibitors respectively.

The team of reseacrchers demonstrated that lower recurrence, lower recurrence-related mortality and lower overall mortality for sirolimus group.

Dr Menon's team concludes, "The review showed lower recurrence rate, longer recurrence-free survival and overall survival and lower recurrence-related mortality in sirolimus-treated patients in comparison with the calcineurin inhibitor-treated patients following liver transplantation for hepatocellular carcinoma."

Aliment Pharmacol Ther 2013: 37(4): 411-9
29 January 2013

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