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Reducing risk for mother-to-infant transmission of Hepatitis C Virus

The latest issue of the Annals of Internal Medicine investigates reducing the risk for mother-to-infant transmission of Hepatitis C virus.

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Dr Erika Barth Cottrell and colleagues evaluated effects of mode of delivery, labor management strategies, and breastfeeding practices on risk for mother-to-infant transmission of hepatitis C virus.

The team searched MEDLINE, the Cochrane Library Database, clinical trial registries, and reference lists.

The team identified randomized trials and observational studies on mode of delivery, labor management strategies, and breastfeeding practices and risk for mother-to-infant transmission of hepatitis C virus.

Investigators abstracted and reviewed study details and quality using predefined criteria.

The research team reported that 18 observational studies evaluated the association between mode of delivery, labor management strategies, or breastfeeding practices and risk for mother-to-infant hepatitis C virus transmission.

The team noted that 14 studies found no clear association between mode of delivery and risk for transmission.

14 studies found no association between breastfeeding and risk for transmission
Annals of Internal Medicine

The doctors observed that 2 studies reported an association between prolonged duration of ruptured membranes and increased risk for transmission.

The team reported that 14 studies found no association between breastfeeding and risk for transmission.

Dr Cottrell's team concludes, "No intervention has been clearly demonstrated to reduce the risk for mother-to-infant HCV transmission."

"Avoidance of breastfeeding does not seem to be indicated for reducing transmission risk."

Annals Int Med:2013 : vol 158, No 2
25 January 2013

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