Psychiatric co-morbidity, in particular major depression and anxiety, is common in patients with Crohn's disease and ulcerative colitis.
Prior studies examining this may be confounded by the co-existence of functional bowel symptoms.
Limited data exist examining an association between depression or anxiety and disease-specific endpoints such as bowel surgery.
Dr Ananthakrishnan and colleagues examined the frequency of depression and anxiety in a large multi-institution electronic medical record (EMR)-based cohort of Crohn's disease and ulcerative colitis patients.
The team defined the independent effect of psychiatric co-morbidity on risk of subsequent surgery or hospitalization in Crohn's disease and ulcerative colitis , and identified the effects of depression and anxiety on healthcare utilization,
Using a multi-institution cohort of patients with Crohn's disease and ulcerative colitis, the team identified those who also had co-existing psychiatric co-morbidity.
|20% had either major depressive disorder or generalized anxiety|
|Alimentary Pharmacology & Therapeutics|
The team of doctors included a total of 5405 Crohn's disease, and 5429 ulcerative colitis patients.
The researchers found that 20% had either major depressive disorder or generalized anxiety.
After the team adjusted for potential confounders and the propensity score, presence of mood or anxiety co-morbidity was associated with a 28% increase in risk of surgery in Crohn's disease.
The researchers found that the psychiatric co-morbidity was associated with increased healthcare utilization.
Dr Ananthakrishnan's team concluded, "Depressive disorder or generalized anxiety is associated with a modestly increased risk of surgery in patients with Crohn's disease."
"Interventions addressing this may improve patient outcomes."