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News

Gastric cancer incidence in pernicious anemia

Published ahead of print, a study in the Alimentary Pharmacology & Therapeutics investigates the risk of pernicious anemia and the development of gastric cancer.

News image

Pernicious anemia has an increased risk for gastric cancer.

It is not established whether pernicious anemia patients need to undergo endoscopic/histological follow-up.

Professor Annibale and colleagues from Italy provided a systematic overview of the literature on pernicious anemia and the development of gastric cancer, to estimate the gastric cancer incidence-rate.

According to PRISMA, the team identified studies on pernicious anemia patients reporting the incidence of gastric cancer.

Quality of studies was evaluated using the Newcastle-Ottawa Quality Assessment Scale.

The calculated pooled gastric cancer incidence-rate was about 0.3% per person-years
Alimentary Pharmacology & Therapeutics

The team performed a meta-analysis on annual gastric cancer incidence rates.

The researchers identified 27 studies that met eligibility criteria.

The team found that 7 studies were of high, 6 of medium, 10 of low and 4 of very low quality.

Gastric cancer incidence-rates ranged from 0% to 0.2% per person-years in 7 American, from 0% to 0.5% in 2 Asiatic, from 0% to 1.2% in 11 Northern European studies, and from 0% to 0.9% in 7 studies from other European countries.

The incidence-rates of gastric cancer ranged from 0% to 1.2% per person-years in studies which used gastroscopy, and from 0.1% to 0.9% in those based on International Classification of Disease.

The team found that heterogeneity between studies was not statistically significant at the 5% level.

The calculated pooled gastric cancer incidence-rate was about 0.3% per person-years.

Meta-analysis showed overall gastric cancer relative risk in pernicious anemia as 6.8.

Professor Annibale's team, "This systematic review shows a pooled gastric cancer incidence-rate in pernicious anemia of 0.3% per person-years, and an estimated nearly 7-fold relative risk of gastric cancer in pernicious anemia patients."

"Further high quality studies are needed to confirm this higher risk."

Aliment Pharmacol Ther 2013: DOI: 10.1111/apt.12177
24 December 2012

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