Prognostic factors for superficial esophageal cancer cannot be limited to such factors as lymph node metastasis, depth of tumor invasion, and genetic alterations.
Dr Eisuke Ito and colleagues examined whether invasive growth patterns of tumors, such as infiltrative growth pattern c (INFc) and budding, represent new useful prognostic factors for superficial esophageal cancer.
The research team investigated 87 cases of superficial esophageal cancer in patients treated with radical surgery.
First, the invasive growth pattern of the tumor was pathologically evaluated based on the traditional infiltrative growth pattern (INF) classification.
Next, new infiltrative growth pattern criteria were proposed, and the invasive pattern was re-evaluated.
|Budding is a prognostic factor|
|Journal of Gastroenterology|
The team also investigated budding in the stroma of the invasive frontal lesion.
When the patients were divided into 2 groups, with and without an infiltrative growth pattern c component, the group with an INFc component had a poorer outcome than the group without an infiltrative growth pattern c component.
When the group with an infiltrative growth pattern c component was defined as 'new INFc', new INFc was correlated with the depth of tumor invasion, and the lymphatic invasion.
Budding was correlated with the depth of tumor invasion, the lymph node metastasis, and new infiltrative growth pattern c.
An analysis of survival revealed new infiltrative growth pattern c, and budding to be prognostic factors.
The research team observed that the survival of the group with new infiltrative growth pattern c(+)/budding(+) was poorer than that with new infiltrative growth pattern c(−)/budding(−).
Dr Ito's team concludes, "New infiltrative growth pattern c and budding, which represent new invasive patterns, were prognostic factors for superficial esophageal cancer."