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Risk estimation for hepatocellular carcinoma in chronic Hepatitis B

A study in published ahead of print in the Alimentary Pharmacology & Therapeutics examines the performance of risk estimation for hepatocellular carcinoma in chronic Hepatitis B.

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The REACH-B Risk Estimation for Hepatocellular Carcinoma in Chronic Hepatitis B scoring system was developed to predict the risk of Hepatocellular carcinoma in noncirrhotic chronic Hepatitis B patients.

Dr Chen and colleagues evaluated the discriminatory performance of REACH-B scoring system in classifying treatment eligibility of chronic Hepatitis B patients according to the 2012 Asian Pacific Association for the Study of the Liver treatment guideline.

The researchers enrolled a total of 904 noncirrhotic chronic Hepatitis B were enrolled.

Patients' age, gender, liver biochemistry, HBeAg status and HBV DNA levels were recorded.

The minimum REACH-B risk score for patients to be eligible for treatment was 7 for HBeAg-positive, and 6 for HBeAg-negative patients.

The researchers noted that increasing REACH-B score was not significantly associated with eligibility for treatment in HBeAg-positive patients, as shown by logistic regression analysis after adjusting for gender.

In HBeAg-negative patients, REACH-B score predicted the treatment eligibility
Alimentary Pharmacology & Therapeutics

The team noted that in HBeAg-negative patients, REACH-B score significantly predicted the treatment eligibility.

Discriminatory ability of REACH-B score to classify eligibility was poor for HBeAg-positive patients 40 years, but good/excellent for HBeAg-positive patients 40 years, HBeAg-negative patients 45 years and HBeAg-negative patients 45 years

Dr Chan concludes "The discriminatory performance of the REACH-B scoring system in classifying treatment eligibility of hepatocellular carcinoma based on the 2012 APASL guideline was good/excellent, except for 40 years old HBeAg-positive patients."

Aliment Pharmacol Ther 2013:
18 December 2012

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