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Paris definition of early Crohn's disease for disease-modification trials

The latest issue of the American Journal of Gastroenterology reports on the development of the Paris definition of early Crohn's disease for disease-modification trials.

News image

Dr Laurent Peyrin-Biroulet and colleagues from France reported the findings and outputs of an international expert opinion process to develop a definition of early Crohn's disease that could be used in future disease-modification trials.

The team reported that 19 experts on inflammatory bowel diseases held an international expert opinion meeting to discuss, and agree on a definition for early Crohn's disease to be used in disease-modification trials.

A published preliminary definition of early Crohn's disease was used as the basis
American Journal of Gastroenterology

The process included literature searches for the relevant basic-science and clinical evidence.

A published preliminary definition of early Crohn's disease was used as the basis for development of a proposed definition that was discussed at the expert opinion meeting.

Dr Biroulet's team concludes "The participants then derived a final definition, based on best current knowledge, that it is hoped will be of practical use in disease-modification trials in Crohn's disease."

Am J Gastroenterol 2012; 107: 1770–1776
17 December 2012

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