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Perceived stress associated with mood disorders in IBD

The latest Inflammatory of Bowel Diseases investigates the causes of mood disorders in inflammatory bowel disease.

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Anxiety and depression are common in patients with inflammatory bowel disease.

However, the factors associated with mood disorders in patients with ulcerative colitis and Crohn's disease are poorly defined.

In all, 103 patients with ulcerative colitis, 101 with Crohn's disease , and 124 healthy controls completed the Hospital Anxiety and Depression Scale (HADS).

Dr Goodhand and colleagues defined the disease activity both from symptom scores and in ulcerative colitis endoscopically, and in Crohn's disease by fecal calprotectin and/or serum C-reactive protein.

Multivariate regression analyses were used to identify factors associated with anxiety and depression.

The doctors observed that in both ulcerative colitis and Crohn's disease , anxiety (HADS-A) and depression (HADS-D) scores were higher than in controls.

There were no differences in the prevalence of mild, moderate, and severe anxiety and depression in ulcerative colitis and Crohn's disease.

The researchers investigated that in ulcerative colitis, anxiety scores were associated with perceived stress and a new diagnosis of IBD.
Depression was associated with active disease
Inflammatory Bowel Diseases

The team noted that depression was associated with stress, inpatient status, and active disease.

In Crohn's disease, anxiety was associated with perceived stress, abdominal pain, and lower socioeconomic status, and depression with perceived stress and increasing age.

Dr Goodhand and his team concludes, "Anxiety and depression are common in inflammatory bowel disease."

"Perceived stress is associated with mood disturbances in both ulcerative colitis and Crohn's disease, but the other associated factors differ in the two diseases."

"Gastroenterologists should look for mood disorders in inflammatory bowel disease and consider stress management and psychotherapy in affected patients."

Inflamm Bowel Dis 2012 :18(12): 2301–2309
13 December 2012

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