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 10 December 2016

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News

Setting priorities for comparative effectiveness research in IBD

The latest issue of the Inflammatory Bowel Diseases developed a priority list of comparative effectiveness research topics for inflammatory bowel disease.

News image

Comparative effectiveness research is an emerging field that compares the relative effectiveness of alternative strategies to prevent, diagnose, or treat patients who are typical of day-to-day practice.

Dr Cheifetz and colleagues developed a priority list of comparative effectiveness research topics for inflammatory bowel disease.

Following the Institute of Medicine's approach, the researchers developed and administered a survey to gastroenterologists asking for important comparative effectiveness research topics in inflammatory bowel disease.

The team convened 2 patient focus groups to solicit additional comparative effectiveness research studies.

The researchers presented comparative effectiveness research topics to the expert panel using the RAND/UCLA methodology.

Following initial ratings, the panel met to discuss and re-rate priorities.

The team reported that the top 10 comparative effectiveness research topics were identified using a point-allocation system.

A point-allocation system prioritized the top-10 comparative effectiveness research topics
Inflammatory Bowel Diseases

Responses were collated into 234 comparative effectiveness research topics across 21 categories, of which 87 were prioritized for discussion and re-rated.

The doctors observed that there was a disagreement regarding priorities that was observed in 5 of 87 studies.

The researchers utilized a point-allocation system to prioritize the top-10 comparative effectiveness research topics.

Those related to comparing the effectiveness of: biomarkers in inflammatory bowel disease included withdrawal of anti-tumor necrosis factor or immunomodulators for Crohn's disease in remission, mucosal healing as an endpoint of treatment, and infliximab levels versus standard infliximab dosing.

The team also examined anti-anti-tumor necrosis factor monotherapy versus combination therapy in patients failing thiopurines, safety of long-term treatment options, anti-anti-tumor necrosis factor versus thiopurines for prevention of postoperative recurrence, and treatment options for steroid-refractory ulcerative colitis.

Dr Cheifetz commented "We systematically developed a list of high-priority inflammatory bowel disease topics for comparative effectiveness research based on a survey of gastroenterologists, expert review, and patient input."

"This list may guide inflammatory bowel disease research toward the most important comparative effectiveness research studies."

Inflammatory Bowel Diseases 2012:18(12): 2294-2300
12 December 2012

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