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Prognosis of colorectal cancer in IBD

The latest issue of the Inflammatory Bowel Diseases examines colorectal cancer-associated inflammatory bowel disease.

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Few data are available on the incidence, characteristics, treatment, and prognosis of inflammatory bowel disease-associated colorectal cancer (CRC) in population-based cohorts.

Dr Laurent Peyrin-Biroulet from France identified all cases of inflammatory bowel disease-associated colorectal cancer among the 19,451 new cases of colorectal cancer recorded in the Burgundy digestive cancer registry between 1976 and 2008.

The incidence rates were age-standardized according to the world standard population.

Prognosis was determined using univariate and multivariate relative survival.

The research team identified 38 inflammatory bowel disease-associated colorectal cancer.
 
The mean age at colorectal cancer diagnosis was greater for patients without inflammatory bowel disease than those with inflammatory bowel disease.

IBD-associated colorectal cancer per 100,000 was 0.11 for men
Inflammatory Bowel Disease

The doctors found that distributions of gender, stage at presentation, location, and histological type of colorectal cancer did not differ from those of sporadic cases.

The overall world age-standardized incidence of inflammatory bowel disease-associated colorectal cancer per 100,000 was 0.11 for men, and 0.06 for women.

The researchers reported that only age was independently associated with inflammatory bowel disease-associated colorectal cancer.

Treatment modalities did not differ between inflammatory bowel disease and non-inflammatory bowel disease patients.

The team found that a 5-year relative survival was 52% in non-inflammatory bowel disease patients, and 41% in inflammatory bowel disease patients.

After adjustment for age, gender, and stage at diagnosis, the excess hazard of death was about 2 times higher in inflammatory bowel disease than in non-IBD patients.

Dr Peyrin-Biroulet's team concluded that "Apart from age, the characteristics of inflammatory bowel disease-associated colorectal cancer were similar to those of non-inflammatory bowel disease colorectal cancer."

"The prognosis of colorectal cancer may be poorer in patients with inflammatory bowel disease than in those without inflammatory bowel disease."

Inflammatory Bowel Diseases: 18 (12)  2247–2251,
07 December 2012

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