Help
Subscribe


Submit Videos to GastroHep Read For FREE - Our full range of review articles
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Guido Tytgat Profile of Pete Peterson Profile of Peter Cotton Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Optimum ribavirin exposure overcomes racial disparity in Hep C genotype 1 treatment

Optimum ribavirin exposure overcomes racial disparity in efficacy of peginterferon and ribavirin treatment for Hepatitis C genotype 1, reports the latest issue of the American Journal of Gastroenterology.

News image

Peginterferon and ribavirin treatment is less effective for hepatitis C virus genotype 1 infections in African Americans compared with Caucasian Americans.
 
Host genetic variability near the interleukin-28B gene locus is partly responsible.
 
Dr Runyan Jin and colleagues from Maryland, USA investigated the relationship between ribavirin drug exposure and week 24 and 72 sustained virologic response.
 
The team examined responses in 71 African Americans, and 74 Caucasian Americans with HCV genotype 1 who received 90% or more of the prescribed peginterferon and weight-based ribavirin from week 1 to 24.
 
Ribavirin plasma levels were measured at weeks 1, 2, 4, 8, 12 and 24.
African Americans had lower ribavirin exposure from week 1 to 12
American Journal of Gastroenterology
 
Ribavirin area under the concentration vs time curve was calculated using the linear trapezoidal rule.
 
The research team found that Caucasian Americans compared with African Americans had a lower week 24 and week 72 sustained virologic response response rates.
 
African Americans also had significantly lower ribavirin exposure from week 1 to 12.
 
The team found that ribavirin exposures of 4,065 and 4,480 ng/ml/day in the first
week were thresholds for WK24VR and sustained virological responses.
 
African Americans were less likely to have a threshold ribavirin AUC0-7 level than Caucasian Americans.
 
The researchers noted that there were no significant racial differences in WK24VR, and rates in patients who met the ribavirin AUC0-7 thresholds.
 
Ribavirin AUC0-7 predicted WK24VR and sustained virological response independently of IL28B single-nucleotide polymorphism rs12979860 genotype.
 
The team noted that achieving threshold AUC0-7 levels increased response rates primarily in AA with the less favorable non-C/C genotypes.
 
Dr Runyan's team concluded that "Standard weight-based dosing leads to suboptimal ribavirin exposure in African Americans and contributes to the racial disparity in peginterferon and ribavirin treatment efficacy for HCV genotype 1."

Am J Gastroenterol 2012; 107:16751683
03 December 2012

Go to top of page Email this page Email this page to a colleague

 28 May 2015

Advanced search
 28 May 2015 
Bleeding and colorectal endoscopic submucosal dissection
 28 May 2015 
Excercise and IBD
 28 May 2015 
Probiotics and Crohn's disease
 27 May 2015 
Management of constipation and IBS
 27 May 2015 
Vegetables and fruit and IBD
 27 May 2015 
Radiofrequency ablation for treatment of GERD
 26 May 2015 
Calcium channel blockers and GI bleeds
 26 May 2015 

Risk factors for celiac disease

 26 May 2015 
Antimicrobials for intraabdominal infection
 25 May 2015 
Risk of GI bleeds with NSAIDs
 25 May 2015 
Colorectal cancer screening
 25 May 2015 
Saccharomyces boulardii and H. pylori
 22 May 2015 
Treatment with anti-integrin antibodies in IBD
 22 May 2015 
Care of patients with GERD
 22 May 2015 
Colonoscopy screening for colorectal cancer
 21 May 2015 
Imaging for hepatocellular carcinoma
 21 May 2015 
Lymphoma in IBD
 21 May 2015 
Serrated polyps and colorectal cancer
 20 May 2015 
Refractory metastatic colorectal cancer
 20 May 2015 
Surveillance in long-segment Barrett's
 20 May 2015 
Pancreatic neuroendocrine tumors
 19 May 2015 
PPIs and cryptogenic liver abscess
 19 May 2015 
Anti-integrin antibodies in IBD
 19 May 2015 
Metabolic syndrome and Barrett's
 18 May 2015 
HLA haplotypes and primary sclerosing cholangitis
 18 May 2015 
Safety of PPI
 18 May 2015 
ESPGHAN celiac guidelines
 15 May 2015 
Management of nonhospitalized ulcerative colitis
 15 May 2015 
Diabetes and infections in IBD with immunomodulation
 15 May 2015 
Microscopic colitis risk with PPIs/NSAIDs
 14 May 2015 
Diagnosis of spontaneous bacterial peritonitis
 14 May 2015 
Mortality in US patients with cirrhosis
 14 May 2015 
Radiation exposure during ERCP
 13 May 2015 
Hypnotherapy in IBS/IBD
 13 May 2015 
Predictors of IBD
 13 May 2015 
Psychological distress and liver disease mortality
 12 May 2015 
Bleeding in NSAID users with H.pylori
 12 May 2015 
Capsule colonoscopy detects colorectal polyps
 12 May 2015 
Anti-TNF biologics in acute severe ulcerative colitis
 11 May 2015 
Management of Barrett's esophagus
 11 May 2015 
Marker to detect recurrence of Crohn's
 11 May 2015 
Thalidomide for IBD
 08 May 2015 
Surveillance colonoscopy in colorectal cancer
 08 May 2015 
HCV treatment with compensated cirrhosis
 08 May 2015 
Medical management of Crohn's
 07 May 2015 
Surgical complications in ulcerative colitis
 07 May 2015 
Combination therapy for noncirrhostic patients
 07 May 2015 
Anxiety and new-onset dyspepsia
 06 May 2015 
PPIs and spontaneous bacterial peritonitis
 06 May 2015 
Infant feeding and celiac disease
 06 May 2015 
Preventing recurrent C. diff infection
 05 May 2015 
Fatigue in primary sclerosing cholangitis
 05 May 2015 
Annual CT scans after esophagectomy for cancer
 05 May 2015 
Prevalence of eosinophilic esophagitis
 04 May 2015 
Stress resilience and peptic ulcer disease
 04 May 2015 
Endoscope storage and microbial colonization
 04 May 2015 
Menarche and NAFLD
 01 May 2015 
Sleep and physical activity measured in Crohn's
 01 May 2015 
NAFLD progression from steatosis to fibrosing-steatohepatitis
 01 May 2015 
Dietary supplement hepatotoxicity

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2015 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us