Help
Subscribe


Submit Videos to GastroHep Read For FREE - Our full range of review articles
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Guido Tytgat Profile of Pete Peterson Profile of Peter Cotton Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Adalimumab plus immunosuppressors improve outcomes in Crohn's disease

December's issue of the Alimentary Pharmacology & Therapeutics investigates co-treatment with immunosuppressors improve outcome in patients with Crohn's disease treated with adalimumab.

News image

There is clear benefit from combination therapy with infliximab and immunosuppressive drugs, but few data are available for adalimumab.
 
Dr Reenaers and colleagues from Belgium assessed the efficacy of adalimumab monotherapy and adalimumab plus immunosuppressive drugs for induction and maintenance therapy in Crohn's disease.
 
Retrospective study of patients with Crohn's disease treated with adalimumab in the United Kingdom or Belgium.

Treatment periods were divided into 6-month semesters.

Successful induction was achieved in 83% of patients
Alimentary Pharmacology & Therapeutics

A combination therapy semester was defined as adalimumab plus immunosuppressive drugs for at least 3 months.

Successful induction meant clinical response, a semester with flare as adalimumab dose escalation, starting steroids, perianal complication, or surgery.

The team reported that adalimumab failure as adalimumab withdrawal for secondary loss of response or intolerance.

The researchers report successful induction in 83% of patients, with no significant difference between adalimumab +IS and adalimumab monotherapy.

The team included 562 semesters in 181 patients for maintenance analysis.

Adalimumab plus immunosuppressive drugs was not associated with fewer semesters with flare, or with adalimumab failure.

Nevertheless, combination therapy in the first semester was associated with a lower risk of adalimumab failure, and combination therapy beyond 6 months was associated with fewer semesters with flares.
 
Dr Reenaers' team concludes, "There may be a benefit from adalimumab plus immunosuppressive drugs combination therapy during the first semester of initiating adalimumab, with a slight decrease in adalimumab failure and lower need for adalimumab dosage escalation."

Aliment Pharmacol Ther 2012: 36(11pt12): 1040–1048
16 November 2012

Go to top of page Email this page Email this page to a colleague

 16 April 2014

Advanced search
 16 April 2014 
Mortality in bleeding Mallory-Weiss syndrome vs peptic ulcer bleeding
 16 April 2014 
Isotretinoin and IBD risk
 16 April 2014 
Evaluating pharmacologic agents in IBS
 15 April 2014 
New prognostic score for cirrhosis
 15 April 2014 
Quality of life in microscopic colitis
 15 April 2014 
Dietary fat and risk of IBD
 14 April 2014 

5-aminosalicylates in early pregnancy and congenital malformation risk

 14 April 2014 
Changing liver cancer mortality rates in the United States
 14 April 2014 
Inflammatory sacroiliitis by MRI in IBD
 11 April 2014 
H pylori resistance to antibiotics
 11 April 2014 
Predictors of corticosteroid treatment outcomes for ulcerative colitis
 11 April 2014 
Antibiotic combination therapy for ulcerative colitis
 10 April 2014 
Mortality in Crohn's disease
 10 April 2014 
Prophylaxis against venous thromboembolism in hospitalized ulcerative colitis
 10 April 2014 
Probiotic treatment and infant colic
 09 April 2014 
Preventing death in general intensive care
 09 April 2014 
Neoplasm risk after polypectomy
 09 April 2014 
Disclosure program and gastroenterology-related claims
 08 April 2014 

Regurgitation and health-related quality of life in GERD

 08 April 2014 
H. pylori resistance to antibiotics
 08 April 2014 
Management of chronic diarrhea
 07 April 2014 
Meat intake and liver cancer
 07 April 2014 
Gastrointestinal angiodysplastic lesions
 07 April 2014 
Adenoma detection and colorectal cancer risk
 04 April 2014 
Stool DNA tests for colorectal cancer
 04 April 2014 
PET-CT predicts outcome in colorectal liver metastases
 04 April 2014 

Prophylaxis of post-ERCP pancreatitis

 03 April 2014 
Management of esophageal or gastric variceal bleeding
 03 April 2014 
Exclusionary diets for IBD
 03 April 2014 
Mortality with chronic pancreatitis
 02 April 2014 
Disease course of early-onset pediatric IBD
 02 April 2014 
Risk of liver fibrosis progression in chronic hep B
 02 April 2014 
Colorectal cancer and patient survival
 01 April 2014 
Outcomes in patients with Hep C
 01 April 2014 
Diagnosis of functional dyspepsia
 01 April 2014 
Genetic risk factors for stenosis and infections in primary sclerosing cholangitis
 31 March 2014 
Diet-gene interactions and Crohn's
 31 March 2014 
Transjugular intrahepatic portosystemic stent-shunts in Budd–Chiari syndrome
 31 March 2014 
Hepatic decompensation in antiretroviral-treated patients
 28 March 2014 
Glucocorticoids and mortality after colorectal cancer surgery
 28 March 2014 
Long-term metformin use and gastric cancer risk
 28 March 2014 
Distance from a liver transplant center and survival
 27 March 2014 
Radiofrequency ablation vs endoscopy for Barrett's
 27 March 2014 
Omega-3 fatty acid and Crohn's disease
 27 March 2014 
Thromboembolism prophylaxis in IBD
 26 March 2014 
Disparities in evaluation of rectal bleeding
 26 March 2014 
Prediction of H. pylori status after endoscopy
 26 March 2014 
Fatigue and depression in IBD
 25 March 2014 
Depression risk in IBD
 25 March 2014 
Fecal incontinence in the USA
 25 March 2014 
Circulating gastrin and colorectal carcinoma risk
 24 March 2014 
Parental-rearing styles in IBS
 24 March 2014 
Endocannabinoid system in liver disease
 24 March 2014 
Maternal iron supplementation during pregnancy
 21 March 2014 
Eosinophilic esophagitis in the United States
 21 March 2014 
Chemoradiotherapy for anal cancer in HIV patients
 21 March 2014 
Diagnostic modalities in gastroenterology
 20 March 2014 
Bacteria in upper GI disease
 20 March 2014 
Combined therapies for variceal bleeding
 20 March 2014 
Therapies for gastric antral vascular ectasia

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2014 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us