Help
Subscribe


All of GastroHep is now free access! - Click here to register Read For FREE - Our full range of review articles
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Guido Tytgat Profile of Pete Peterson Profile of Peter Cotton Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Preoperative oral antibiotics reduce infections after colorectal resections

Preoperative oral antibiotics reduce surgical site infection following elective colorectal resections, finds this month's issue of the Diseases of the Colon & Rectum.

News image

Surgical site infection is a major cause of morbidity after colorectal resections.

Despite evidence that preoperative oral antibiotics with mechanical bowel preparation reduce surgical site infection rates, the use of oral antibiotics is decreasing.

Currently, the administration of oral antibiotics is controversial and considered ineffective without mechanical bowel preparation.

Dr Jamie Cannon and colleagues examined the use of mechanical bowel preparation and oral antibiotics, and their relationship to surgical site infection rates in a colorectal Surgical Care Improvement Project cohort.

Those receiving oral antibiotics alone had a surgical site infection rate of 8%
Diseases of the Colon & Rectum

The team used Veterans Affairs Surgical Quality Improvement Program preoperative risk, and surgical site infection outcome data linked to Veterans Affairs Surgical Care Improvement Project and Pharmacy Benefits Management data.

The researchers identify factors associated with surgical site infection within 30 days of surgery conducted in 112 Veterans Affairs hospitals.

The team evaluated 9940 patients who underwent elective colorectal resections from 2005 to 2009.

The researchers' primary outcome measured was the incidence of surgical site infection.

Patients receiving oral antibiotics had significantly lower surgical site infection rates.

Those receiving no bowel preparation had similar surgical site infection rates to those who had mechanical bowel preparation only.

The team found that those receiving oral antibiotics alone had a surgical site infection rate of 8%, and those receiving oral antibiotics plus mechanical bowel preparation had a rate of 9%.

In adjusted analysis, the use of oral antibiotics alone was associated with a 67% decrease in surgical site infection occurrence.

Oral antibiotics plus mechanical bowel preparation was associated with a 57% decrease in surgical site infection occurrence.

The research team noted that timely administration of parenteral antibiotics had a modest protective effect, with no effect observed for other Surgical Care Improvement Project measures.

The researchers found that hospitals with higher rates of oral antibiotics use had lower surgical site infection rates.

Dr Cannon's team concludes, "Use and type of preoperative bowel preparation varied widely."

"These results strongly suggest that preoperative oral antibiotics should be administered for elective colorectal resections."

"The role of oral antibiotics independent of mechanical bowel preparation should be examined in a prospective randomized trial."

Dis Colon Rectum 2012: 55(11): 1160–1166
13 November 2012

Go to top of page Email this page Email this page to a colleague

 05 August 2015

Advanced search
 05 August 2015 
Gender differences in fecal immunochemical tests
 05 August 2015 
Adenoma detection rates with a screening colonoscopy program
 05 August 2015 
Extraintestinal manifestations in IBD diagnosis
 04 August 2015 
IBD environmental risk factors
 04 August 2015 
Measuring disease activity in Crohn's
 04 August 2015 
Gastric emptying and hyperglycemia in diabetes
 03 August 2015 
Vaccinations and IBD
 03 August 2015 
Lack of response to therapy in severe ulcerative colitis
 03 August 2015 
Nutritional vs biological therapy in Crohn's
 31 July 2015 
Prognostic index for hep C-related cirrhosis
 31 July 2015 
Risk of hepatocellular carcinoma in chronic HCV with diabetes
 31 July 2015 
Reducing surgical site infection after stoma reversal
 30 July 2015 
Post-colonoscopy colorectal cancer rates
 30 July 2015 
Venous thromboembolism in colorectal surgery
 30 July 2015 
Saccharomyces boulardii for antibiotic-associated diarrhea
 29 July 2015 
Sitafloxacin-based triple therapy for H.pylori
 28 July 2015 
Lifestyle changes after colorectal cancer screening
 27 July 2015 
Fecal microbiota transplantation for severe C. difficile infection
 24 July 2015 
Causes of death in celiac disease
 23 July 2015 
Reduction in H. pylori prevalence
 22 July 2015 
Detection of esophageal eosinophilia and eosinophilic esophagitis
 21 July 2015 

Clinical outcomes for Barrett's esophagus neoplasia

 20 July 2015 
Certolizumab pegol for Crohn's disease
 17 July 2015 
Genetic variation and gastric cancer
 17 July 2015 
Colitis associated with anti-CTLA-4 therapy
 17 July 2015 

Sexual dysfunction after rectal cancer treatment

 16 July 2015 
Lynch syndrome screening by microsatellite instability
 16 July 2015 
Hormones and endometrial cancer in Lynch syndrome
 16 July 2015 
Relapse of IBD after discontinuation of anti-TNF therapy
 15 July 2015 
Risk prediction index for advanced colorectal cancer
 15 July 2015 
Aspergillus niger-derived enzymes
 15 July 2015 
Prophylactic omeprazole improves GI symptoms
 14 July 2015 
Interferon- and ribavirin-free treatment regimen for HCV
 14 July 2015 
Combination therapies for chronic HCV
 14 July 2015 
Cancer surveillance in ulcerative colitis
 13 July 2015 
Colon polyps in chronic inflammatory conditions of the colon
 13 July 2015 
Drugs and occult vs overt upper GI bleeds
 13 July 2015 
Anxiety and depression in functional GI disorders
 10 July 2015 
Daclatasvir in the treatment of chronic HCV
 10 July 2015 
Surveillance intervals to reduce colorectal cancer
 10 July 2015 
Stress and GI symptoms in IBD
 09 July 2015 
Opioid-induced esophageal dysfunction
 09 July 2015 
Marker of response to medical therapy in Crohn's
 09 July 2015 
Predictive factors for metastasis in colorectal cancer
 08 July 2015 
Chronic unexplained nausea and vomiting
 08 July 2015 

Nucleoside analogue therapy in HBeAg-negative chronic hepatitis B?

 08 July 2015 

Medical education in endoscopy training

 07 July 2015 
Anastomotic leak after elective surgery for colonic cancer
 07 July 2015 
Fecal transplantation for ulcerative colitis
 07 July 2015 
Obesity and risk of hepatocellular carcinoma
 06 July 2015 
Fecal microbiota transplantation
 06 July 2015 
Liver Failure–Sequential Organ Failure Scoring System
 06 July 2015 
Future colorectal surgery for metachronous cancers
 03 July 2015 
Tumors with mismatch-repair deficiency
 03 July 2015 
Aptitude of trainees in endoscopic ultrasonography
 03 July 2015 
Extracolonic pathologies in colorectal cancer
 02 July 2015 
Ulcerative colitis prognosis after thiopurines withdrawal
 02 July 2015 
Anastomotic leak and cancer cancer
 02 July 2015 
Health care use by IBD children
 01 July 2015 
Missed gastric cancers

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2015 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us