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Eradication of Helicobacter pylori infection by probiotic strains

The latest issue of Helicobacter examines the ability of Lactobacillus spp. to inhibit Helicobacter pylori infection.

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The current therapy for Helicobacter pylori infection includes antimicrobial agents and proton pump inhibitors.

Dr King and colleagues from Taiwan examined the ability of Lactobacillus spp. to inhibit H. pylori infection.
 
Probiotic strains isolated from samples of adult feces, infant feces, breast milk, and vaginal swab collected from healthy volunteers in Taiwan, and commercially available strains were screened for antagonism toward H. pylori.

Inhibition liquid culture assay was used to screen potential anti-H. pylori activity.

The research team performed agar plate inhibition assay, and assays to determine the capacity of probiotics for adhesion, and inhibition and killing of H. pylori.

The team then measured the levels of IL-8 and IL-10.

6 of the tested strains suppressed urease activity of H. pylori
Helicobacter

Using animal models, the researchers studied regulation of gastric acid and histopathological changes accompanying anti-H. pylori activity.
 
The team found that 6 of the tested strains suppressed urease activity of H. pylori.

The researchers observed that Lactobacillus acidophilus TYCA08, L. acidophilus TYCA15, L. johnsonii MH-68, and L. salivarius subsp. salicinius AP-32 were more effective than the others.

In vivo, L. johnsonii MH-68 and L. salivarius subsp. salicinius AP-32 alone or in combination, reduced the H. pylori load in the gastric mucosa, and also reduced inflammatory chemokine expression and lymphocyte infiltration.
 
Dr King's team concludes, "Lactobacillus johnsonii MH-68 and L. salivarius subsp. salicinius AP-32 effectively suppress H. pylori viability."

"When used as probiotics, they may help decrease the occurrence of gastritis, and even reduce the risk of H. pylori infection."

Helicobacter 2012: 17(6): 466–477
13 November 2012

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