Help
Subscribe


Submit Videos to GastroHep Read For FREE - Our full range of review articles
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Guido Tytgat Profile of Pete Peterson Profile of Peter Cotton Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

High body mass index patients have lower stages of esophageal carcinoma at diagnosis

Patients with high body mass index tend to have lower stage of esophageal carcinoma at diagnosis, reports the latest issue of the Diseases of the Esophagus.

News image

High body mass index is common in US adults.

In a small cohort of esophageal cancer patients treated with surgery, high-BMI and diagnosis of early stage esophageal cancer appeared associated.

Dr Jaffer Ajani and colleagues from Texas, USA evaluated a much larger cohort of esophageal cancer patients.

From a prospectively maintained database, the team analyzed 925 esophageal cancer patients who had surgery with or without adjunctive therapy.

Various statistical methods were used.

High-BMI patients do not experience higher rate of surgical complications
Diseases of the Esophagus

Among 925 patients, 69% had high-BMI, and 31% had normal body mass index.

High-BMI was associated with men, Caucasians, lower esophageal localization, adenocarcinoma histology, low baseline cT-stage, low baseline overall clinical stage, coronary artery disease, and diabetes.

The researchers found that normal-BMI was associated with weight loss, alcohol abuse, ever/current smoking, and baseline cN+.

High-BMI patients with cT1 tumors had significantly higher rates of gastresophageal reflux disease symptoms, gastresophageal reflux disease history, and Barrett's esophagus history compared with H-BMI patients with cT2 tumors.

The team noted that the median survival of normal-BMI patients was 37 months compared with 53 months for high-BMI patients.

The researchers found that older age, squamous histology, smoking, weight loss, high baseline stage, high number of ypN+, high surgical stage, and American Society of Anesthesia scores, 3 out of 4 were independent prognosticators for poor overall survival.

The researchers were able to perform propensity-based analysis of surgical complications between high-BMI and normal-BMI patients.

A comparison of fully matched 376 patients found no significant differences in the rate of complications between the 2 groups.

The team confirmed that a fraction of high-BMI patients with antecedent history is diagnosed with early baseline esophageal cancer.

Dr Ajani's team concludes, "Upon validation of our data in an independent cohort, refinements in surveillance of symptomatic high-BMI patients are warranted and could be implemented."

"Our data also suggest that high-BMI patients do not experience higher rate of surgical complications compared with normal-BMI patients."

Dis Esoph 2012: 25(7): 614–622
24 October 2012

Go to top of page Email this page Email this page to a colleague

 22 August 2014

Advanced search
 22 August 2014 
Endoscopic submucosal dissection for squamous esophageal cancer
 22 August 2014 
Adherence to Rome criteria in functional dyspepsia trials
 22 August 2014 
Outlier identification in colorectal surgery
 21 August 2014 
Screening for Barrett’s esophagus
 21 August 2014 
Colorectal cancer mortality in Brazil
 21 August 2014 
Eosinophilic esophagitis
 20 August 2014 
Rectal surgery mortality
 20 August 2014 
Chemotherapy-induced gastrointestinal mucositis
 20 August 2014 
Stool methylated DNA markers and colorectal cancer resection
 19 August 2014 
Recurrent C. difficile infection in out-patients
 19 August 2014 
Racial disparities and colon cancer
 19 August 2014 
Variability of colonoscopy preparation instructions
 18 August 2014 
The evolution of urban C. difficile
 18 August 2014 
Metabolomic analysis in IBD
 18 August 2014 
Enhanced T-cell response in acute-on-chronic Hep B
 15 August 2014 
Abdominal pain in IBS
 15 August 2014 
Gene expression biomarker in ulcerative colitis
 15 August 2014 
Population-based fecal immunochemical test screening
 14 August 2014 
Transnasal vs transoral endoscopy
 14 August 2014 
Radiation exposure in gastroenterology
 14 August 2014 
Dietary fibre and diverticular disease
 13 August 2014 
Flexible sigmoidoscopy screening
 13 August 2014 
Adherence to Rome criteria in functional dyspepsia
 13 August 2014 
Fecal immunochemical test screening
 12 August 2014 
Eosinophilic esophagitis and celiac disease
 12 August 2014 
Management of Lynch syndrome
 12 August 2014 
Risk of cancer under immunosuppressive therapy in IBD
 11 August 2014 
Risk of GI bleeds with anticoagulants
 11 August 2014 
Social media in health-care
 11 August 2014 
Gut microbiota in chemotherapy-induced GI mucositis
 08 August 2014 
Endoscopy nurse-administered propofol sedation performance
 08 August 2014 
Therapy for biliary tract cancer
 08 August 2014 
Surgeon volume and esophagectomy survival
 07 August 2014 
Global consensus on perianal fistulizing Crohn's disease
 07 August 2014 
Smoking cessation and age of onset of ulcerative colitis
 07 August 2014 
Colonoscopy length and training duration
 06 August 2014 
Hepatitis C virus infection in the United States
 06 August 2014 
Pediatric to adult IBD care
 06 August 2014 
Biomarker of disease activity in IBD
 05 August 2014 
Rising incidence of celiac disease
 05 August 2014 
Socioeconomic status and IBS
 05 August 2014 
Bowel dysfunction after sphincter-preserving rectal cancer surgery
 04 August 2014 
Relative adrenal insufficiency and chronic liver disease
 04 August 2014 
Colonoscopy screening protocol for liver transplant recipients
 04 August 2014 
Patient-reported outcomes after upper GI bleed
 01 August 2014 
Capsule colonoscopy vs CT colonography for polyp screening
 01 August 2014 
Complications after obesity surgery
 01 August 2014 
Fully covered self-expanding metal stents for benign biliary strictures
 31 July 2014 
Biomarkers in liver fibrosis
 31 July 2014 
Risk factors of large colorectal polyps
 31 July 2014 
Diverticular disease and colon cancer
 30 July 2014 
Small intestinal permeability in diarrhea predominant IBS
 30 July 2014 
Mineral rich water and constipation
 30 July 2014 
Interval between screening colonoscopies
 29 July 2014 
Fluticasone in eosinophilic esophagitis
 29 July 2014 
Causes of GI bleeding in cirrhosis
 29 July 2014 
ALT increases in Hep B
 28 July 2014 
Statins reduce Barrett's
 28 July 2014 
Score predicts risk for Barrett’s esophagus
 28 July 2014 
Gastric cancer prevention

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2014 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us