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H. pylori cure leads to remission of gastric mucosa-associated lymphoid tissue lymphoma

A study in the latest issue of Gastroenterology investigates second cancers and residual disease in patients treated for gastric mucosa-associated lymphoid tissue lymphoma by H. pylori eradication.

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Cure of Helicobacter pylori infection induces remission in most patients with gastric mucosa-associated lymphoid tissue lymphoma that is associated with these bacteria.

Dr Thomas Wündisch and colleagues determined the long-term outcomes of these patients in a prospective multicenter trial, and investigated whether they developed second cancers or had histologic residual disease.

The research team followed 120 patients with stage EI1 gastric mucosa-associated lymphoid tissue lymphoma for a median of 122 months after H. pylori eradication.

80% achieved complete remission
Gastroenterology

Remission was determined by histology analysis and development of second cancers was documented.

Of the patients, 80% achieved complete remission from gastric mucosa-associated lymphoid tissue lymphoma, and 80% of those remained disease free.

Estimated mean survival time in the Kaplan–Meier analysis was 147 months.

Of the patients that achieved complete remission, the team found that 17% had histologic residual disease after a median of 32 months.

The team observed that disease did not progress in any of these patients, and all but 1 achieved a second complete remission.

The researchers revealed a significantly higher incidence of gastric cancer or non-Hodgkin lymphoma in the 96 patients that achieved a complete remission, compared with the general German population.

Dr Wündisch's team commented, "Cure of H. pylori infection leads to continuous complete remission in most patients with H. pylori–associated gastric mucosa-associated lymphoid tissue lymphoma."

"Patients are at risk for development of secondary cancers."

Gastroenterology 2012: 143(4): 936-942
05 October 2012

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