Few large population-based studies have compared the occurrence of peptic ulcer bleeding in cirrhotic and noncirrhotic patients.
Dr Luo and colleagues from Taiwan investigated if cirrhotic patients have higher risk of peptic ulcer bleeding than the general population, and identified possible risk factors of peptic ulcer bleeding in cirrhotic patients.
|Cirrhotic patients had higher incidences of peptic ulcer bleeding|
|Alimentary Pharmacology & Therapeutics|
Using the National Health Insurance Research Database, a nationwide population-based dataset in Taiwan and matching age, gender, comorbidities and ulcerogenic medication by propensity score, 4013 cirrhotic patients, 8013 chronic hepatitis patients and 7793 normal controls were compared.
During the 7-year follow-up, the team found that cirrhotic patients had significantly higher incidences of peptic ulcer bleeding than chronic hepatitis patients and controls, respectively.
The researchers found that cirrhosis was independently associated with increased risk of peptic ulcer bleeding after adjusting for age, gender, economic status, underlying comorbidities and ulcerogenic medication.
Age, male, diabetes, chronic renal disease, history of gastro-esophageal variceal bleeding and use of nonsteroidal anti-inflammatory drugs were risk factors for peptic ulcer bleeding in cirrhotic patients.
Dr Luo's team concludes, "Cirrhotic patients have a significantly higher risk of peptic ulcer bleeding after adjustments for possible confounding factors like age, gender, economic status, underlying comorbidities and ulcerogenic medication."