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It is well established that acute pancreatitis often causes diabetes mellitus. However, whether pre-existing diabetes is associated with the development of acute pancreatitis remains unknown. To clarify the association of pre-existing diabetes and the development of acute pancreatitis, Dr Yuzhenga Xue and colleagues carried out a meta-analysis of observational studies. The research team performed a computerized literature search in MEDLINE and EMBASE through 2012. The team also searched the reference lists of relevant articles.  | | Diabetic individuals had a 92% increased risk of development of acute pancreatitis | | European Journal of Gastroenterology |
The team included a total of 7 articles in the meta-analysis. The research team found that compared with nondiabetic individuals, diabetic individuals had a 92% increased risk of development of acute pancreatitis. There was significant evidence of heterogeneity among these studies. These increased risks were independent of alcohol use, gallstones, and hyperlipidemia. Dr Xue's team commented, "Although the current evidence supports a positive link between pre-existing diabetes and an increased risk of development of acute pancreatitis, additional studies, with a perfect design, are required before definitive conclusions can be drawn."
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