Clostridium difficile-associated disease with frequent watery stools, sometimes with painful bowel movements, fever and sickness, is probably the major known cause of antibiotic-associated diarrhea and colitis.
This depends on a disruption of the normal intestinal balance in the microbiome.
|69% of patients were durably cured|
|Scandanavian Journal of Gastroenterology|
Dr Christina Jorup-Rönström and colleagues from Sweden inoculated a mixture of fecal microbes – as an enema – originating from a healthy Scandinavian middle-aged donor, regularly re-cultivated under strict anerobic conditions for more than 10 years, to 32 patients.
The team found that 69% of patients were durably cured.
In those patients receiving the transplant by colonoscopy, the team reported that 4 out of 5 were cured.
Dr Jorup-Rönström's team concludes, "To the best of our knowledge, this is the first time a fecal culture of microbes has retained the possibility for years to cure a substantial number of patients with Clostridium difficile-associated disease."