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 16 January 2018

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News

Additional research finds that sildenafil inhibits esophageal motility

Sildenafil may be a useful treatment option in esophageal motor disorders that have defects in nitric oxide neuromuscular communication, find researchers from Seoul, Korea.

News image

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The team investigated the effect of sildenafil (Viagra) on lower esophageal sphincter (LES) and body motility in normal male adults.

They reported their findings in the December issue of the American Journal of Gastroenterology.

Sildenafil relaxes smooth muscle by blocking type 5 phosphodiesterase, which destroys nitric oxide-stimulated cyclic guanosine monophosphate.

Basal esophageal manometry was conduced in 8 healthy male adult volunteers.

The researchers then infused a 50-mg tablet of sildenafil, dissolved in water, in the stomach through the manometry catheter.

LES resting pressure significantly decreased after sildenafil infusion.
American Journal of Gastroenterology

Changes of LES and body motility were observed with the lapse of time.

The study population was randomized into 2 groups. Esophageal manometry was repeated in LES and body sequence in 4 volunteers, and in body and LES sequence in the other 4 volunteers immediately after sildenafil infusion.

It was found that LES resting pressure significantly decreased after sildenafil infusion.

It was also discovered that the body peristaltic amplitude gradually decreased and eventually disappeared, and the latency increased significantly after sildenafil infusion in both the proximal and distal esophagus.

Author P. L. Rhee, of the Sungkyunkwan University School of Medicine in Seoul, said on behalf of fellow authors, "These data support that nitric oxide mediates LES relaxation and the timing of esophageal peristalsis."

"In the future, sildenafil can be tried in some esophageal motor disorders, which have defects in nitric oxide neuromuscular communication," it was concluded.

In October, GastroHep.com reported that sidenafil was found to inhibit esophageal motility. To read this story please click here.

Am J Gastroenterol 2001; 96(12): 3251-7
30 January 2002

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