Few studies have investigated measures to prevent small bowel injuries induced by aspirin.
Dr Hiroki Endo and colleagues evaluated the effect of probiotic treatment on the small bowel injuries induced by chronic low-dose aspirin use.
The research team evaluated 35 patients who took low-dose enteric-coated aspirin 100 mg daily plus omeprazole 20 mg daily, and were diagnosed as having unexplained iron deficiency anemia participated in this prospective randomized controlled trial.
The researchers assigned the patients to receive probiotic treatment with Lactobacillus casei for 3 months or not receive the probiotic.
|The median capsule endoscopy score in the L. casei group was −228 |
|Journal of Gastroenterology|
Patients underwent capsule endoscopy before and after treatment.
The team found that 25 patients, including 13 in the Lactobacillus casei group and 12 in the control group, underwent the full analysis.
Significant decreases in the number of mucosal breaks and the capsule endoscopy score were observed at the 3-month evaluation in the Lactobacillus casei group as compared with the results in the control group.
The researchers observed that change from the baseline in the median number of mucosal breaks in the Lactobacillus casei group was −2, as compared with 0.5 in the control group.
The research team found that change from the baseline in the median capsule endoscopy score in the Lactobacillus casei group was −228 compared with −4 in the control group.
Dr Endo's team commented, "Co-administration of Lactobacillus casei is effective for the treatment of aspirin-associated small bowel injury."