Drs Stanley Cohen and Alan Klevens from Georgia, USA systematically reviewed compiled data on indications and outcomes, and evaluated the effectiveness of capsule endoscopy on patient management using meta-analyses.
The researchers searched the Medline and PubMed databases for English language citations of use of capsule endoscopy in patients 18 years old or less.
Duplicate reports and those that included 5 patients or fewer were removed.
The research team analyzed data from 15 source documents with 740 capsule endoscopy procedures in 723 patients.
|65% of procedures resulted in positive findings|
|Clinical Gastroenterology & Hepatology|
Suspicion or evaluation of inflammatory bowel diseases was the most common indication for capsule endoscopy.
Completion and retention rates were 86% and 3%, respectively.
The research team found that retention rates for children that underwent gastric or small bowel capsule endoscopy were similar to those of adults, by indication.
For capsule endoscopy, 65% of procedures resulted in positive findings.
Where reported, the researchers found that 69% of capsule endoscopy examinations resulted in a new diagnosis, and 68% led to change in therapy.
Dr Cohen's team concluded, "The relative frequency of capsule endoscopy indications varies among pediatric and adult patients."
"In pediatric patients, capsule endoscopy is used primarily to evaluate patients with celiac disease — to aid in diagnosis, monitor disease severity, and assist patient management."
"Retention rates appear to be related to indication, rather than patient age."
"Capsule retention is relatively infrequent for adults and children."