A team from Uppsala, Sweden, investigated whether patients with psoriatic arthritis have an increased prevalence of antibodies to gliadin (AGA) and of celiac disease.
A total of 114 psoriatic arthritis patients with skin disease of a mean of 20 years and joint disease of 11 years duration were included in the study.
All answered a questionnaire concerning their medical history and underwent clinical examination, including radiology.
Serum IgA AGA and IgG AGA, IgA antibodies to endomysium and immunoglobulins, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) concentration were all determined.
Of the 114 patients, 5 (4.4%) had celiac disease.
| Serum gliadin antibody levels significantly higher among psoriatic arthritics.
| Rheumatology |
After exclusion of these 5 patients, the mean IgA AGA concentration was found to be significantly higher than that in a reference group.
None of the patients had IgA antibodies to endomysium.
The researchers found that mean serum IgA concentration was significantly increased, and IgM decreased.
Patients with a high concentration of IgA AGA had significantly higher ESR and CRP, and a longer duration of morning stiffness, than those with a low AGA concentration.
Author U. Lindqvist, of the University Hospital in Uppsala, concluded on behalf of the group, "Patients with psoriatic arthritis have an increased prevalence of raised serum IgA AGA and of celiac disease.
"In addition, patients with raised IgA AGA seem to have more pronounced inflammation than those with a low IgA AGA concentration."